8ONK

Human insulin in complex with the analytical antibody S1 Fab and the analytical antibody HUI-001 Fab

Summary for 8ONK

Entry DOI	10.2210/pdb8onk/pdb
Descriptor	Heavy chain of analytical antibody S1 Fab, Light chain of analytical antibody S1 Fab, Insulin A chain, ... (6 entities in total)
Functional Keywords	insulin, analytical antibody, hui-001, hormone
Biological source	Mus musculus More
Total number of polymer chains	12
Total formula weight	200879.67
Authors	Johansson, E. (deposition date: 2023-04-03, release date: 2024-04-10, Last modification date: 2025-10-22)
Primary citation	Christoffersen, S.,Baumann, K.,Millner, A.H.,Toft-Hansen, H.,Johansson, E.,Thorlaksen, C.,Skov, P.S. IgE clonality and aggregation of insulin affect IgE-mediated activation of sensitized basophils. J Allergy Clin Immunol Glob, 4:100502-100502, 2025 Cited by PubMed Abstract: Skin prick testing and specific IgE determination do not discriminate between sensitization and clinically relevant insulin allergic reactions, whereas the basophil histamine release assay has proven useful in identifying clinically relevant food and drug allergic reactions. PubMed: 40583959 DOI: 10.1016/j.jacig.2025.100502 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.403 Å)

Structure validation