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PDB: 480 件
1E0F
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Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor
分子名称: HAEMADIN, THROMBIN
著者Richardson, J.L, Kroeger, B, Hoefken, W, Pereira, P, Huber, R, Bode, W, Fuentes-Prior, P.
登録日2000-03-27
公開日2000-11-03
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystal Structure of the Human Alpha-Thrombin-Haemadin Complex: An Exosite II-Binding Inhibitor
Embo J., 19, 2000
7NTU
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X-ray structure of the complex between human alpha thrombin and two duplex/quadruplex aptamers: NU172 and HD22_27mer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, HD22_27mer, ...
著者Troisi, R, Santamaria, A, Sica, F.
登録日2021-03-10
公開日2021-04-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural and functional analysis of the simultaneous binding of two duplex/quadruplex aptamers to human alpha-thrombin.
Int.J.Biol.Macromol., 181, 2021
1NRO
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CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES
分子名称: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), RECEPTOR BASED PEPTIDE NRP
著者Tulinsky, A, Mathews, I.I.
登録日1994-01-18
公開日1994-05-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
Biochemistry, 33, 1994
1NRN
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CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES
分子名称: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), RECEPTOR BASED PEPTIDE NRS
著者Tulinsky, A, Mathews, I.I.
登録日1994-01-18
公開日1994-05-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
Biochemistry, 33, 1994
1SR5
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ANTITHROMBIN-ANHYDROTHROMBIN-HEPARIN TERNARY COMPLEX STRUCTURE
分子名称: 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-deoxy-2,3,6-tri-O-methyl-alpha-D-xylo-hexopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfo-alpha-D-glucopyranose-(1-4)-(2R,3R,4S,5S,6S)-6-(dihydroxymethyl)-3,4-dimethoxytetrahydro-2H-pyran-2,5-diol-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-(2R,3R,4S,5S,6R)-6-(dihydroxymethyl)-3,4-dimethoxytetrahydro-2H-pyran-2,5-diol-(1-4)-1,5-anhydro-3-O-methyl-2,6-di-O-sulfo-D-glucitol, ...
著者Dementiev, A, Petitou, M, Gettins, P.G.
登録日2004-03-22
公開日2004-08-17
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity.
Nat.Struct.Mol.Biol., 11, 2004
1DWB
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CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
分子名称: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), BENZAMIDINE, ...
著者Banner, D.W, Hadvary, P.
登録日1992-08-19
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (3.16 Å)
主引用文献Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors.
J.Biol.Chem., 266, 1991
7ZKL
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X-ray structure of the complex between human alpha thrombin and a pseudo-cyclic thrombin binding aptamer (TBA-NNp/DDp) - Crystal form alpha
分子名称: (2S)-2-hydroxybutanedioic acid, 3-[13-methyl-5,7,12,14-tetrakis(oxidanylidene)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(15),2,4(16),8,10-pentaen-6-yl]propyl 3-[5,7,12,14-tetrakis(oxidanylidene)-13-(3-oxidanylpropyl)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1,3,8(16),9,11(15)-pentaen-6-yl]propyl hydrogen phosphate, 3-[5-[3-bis(oxidanyl)phosphanyloxypropoxy]naphthalen-1-yl]oxypropyl 3-(5-oxidanylnaphthalen-1-yl)oxypropyl hydrogen phosphate, ...
著者Troisi, R, Sica, F.
登録日2022-04-13
公開日2022-11-30
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.18 Å)
主引用文献A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers.
Mol Ther Nucleic Acids, 30, 2022
4E06
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Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Salivary anti-thrombin peptide anophelin, ...
著者Figueiredo, A.C, de Sanctis, D, Gutierrez-Gallego, R, Cereija, T.B, Macedo-Ribeiro, S, Fuentes-Prior, P, Pereira, P.J.B.
登録日2012-03-02
公開日2012-12-05
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.196 Å)
主引用文献Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector.
Proc.Natl.Acad.Sci.USA, 109, 2012
3PMH
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Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct alpha-Thrombin Sites
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide, Platelet glycoprotein Ib alpha chain, ...
著者Varughese, K.I, Celikel, R.
登録日2010-11-16
公開日2011-06-01
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Binding of alpha-thrombin to surface-anchored platelet glycoprotein Ib(alpha) sulfotyrosines through a two-site mechanism involving exosite I.
Proc.Natl.Acad.Sci.USA, 108, 2011
2BVX
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BU of 2bvx by Molmil
Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-P2-Linker
分子名称: ALPHA THROMBIN, HIRUDIN VARIANT-2, N-(5-CHLORO-BENZO[B]THIOPHEN-3-YLMETHYL)-2-[6-CHLORO-OXO-3-(2-PYRIDIN-2-YL-ETHYLAMINO)-2H-PYRAZIN-1-YL]-ACETAMIDE
著者Bulat, S, Bosio, S, Grabowski, E, Papadopoulos, M.A, Cerezo-Galvez, S, Rosenbaum, C, Matassa, V.G, Ott, I, Metz, G, Schamberger, J, Sekul, R, Feurer, A.
登録日2005-07-04
公開日2006-10-25
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Design and Discovery of Novel, Potent Pyrazinone-Based Thrombin Inhibitors with a Solubilizing P1-P2-Linker
Lett.Drug Des.Discovery, 3, 2006
8UF7
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BU of 8uf7 by Molmil
Cryo-EM structure of POmAb, a Type-I anti-prothrombin antiphospholipid antibody, bound to kringle-1 of human prothrombin
分子名称: POmAb Heavy Chain, POmAb Light Chain, Prothrombin
著者Kumar, S, Summers, B, Basore, K, Pozzi, N.
登録日2023-10-03
公開日2024-02-14
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Cryo-EM structure and functional basis of prothrombin recognition by a type I antiprothrombin antiphospholipid antibody.
Blood, 143, 2024
5EDK
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Crystal structure of prothrombin deletion mutant residues 146-167 ( Form II ).
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ...
著者Pozzi, N, Chen, Z, Di Cera, E.
登録日2015-10-21
公開日2016-01-20
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.214 Å)
主引用文献How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin.
J.Biol.Chem., 291, 2016
2HPP
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Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human ppack-thrombin
分子名称: ALPHA-THROMBIN HEAVY CHAIN, ALPHA-THROMBIN LIGHT CHAIN, D-phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide, ...
著者Tulinsky, A, Padmanabhan, K.
登録日1993-04-28
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin.
Biochemistry, 32, 1993
2HPQ
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Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human ppack-thrombin
分子名称: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), D-phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide, ...
著者Tulinsky, A, Padmanabhan, K.
登録日1993-04-28
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin.
Biochemistry, 32, 1993
6P9U
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Crystal structure of human thrombin mutant W215A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin, ZINC ION
著者Pelc, L.A, Koester, S.K, Chen, Z, Di Cera, E.
登録日2019-06-10
公開日2019-09-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin.
Sci Rep, 9, 2019
4HZH
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Structure of recombinant Gla-domainless prothrombin mutant S525A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin
著者Pozzi, N, Niu, W, Gohara, D.W, Chen, Z, Di Cera, E.
登録日2012-11-15
公開日2013-06-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation.
J.Biol.Chem., 288, 2013
4O03
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Crystal structure of Ca2+ bound prothrombin deletion mutant residues 146-167
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Prothrombin
著者Pozzi, N, Chen, Z, Shropshire, D.B, Pelc, L.A, Di Cera, E.
登録日2013-12-13
公開日2014-05-21
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (3.38 Å)
主引用文献The linker connecting the two kringles plays a key role in prothrombin activation.
Proc.Natl.Acad.Sci.USA, 111, 2014
1NRQ
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CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES
分子名称: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), RECEPTOR BASED PEPTIDE D-FPR'S
著者Tulinsky, A, Mathews, I.I.
登録日1994-01-18
公開日1994-05-31
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
Biochemistry, 33, 1994
5EW2
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BU of 5ew2 by Molmil
Human thrombin sandwiched between two DNA aptamers: HD22 and HD1-deltaT12
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, HD1-deltaT12, ...
著者Pica, A, Russo Krauss, I, Parente, V, Sica, F.
登録日2015-11-20
公開日2016-11-30
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.59 Å)
主引用文献Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers.
Nucleic Acids Res., 45, 2017
2A45
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BU of 2a45 by Molmil
Crystal structure of the complex between thrombin and the central "E" region of fibrin
分子名称: D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Fibrinogen alpha chain, Fibrinogen beta chain, ...
著者Pechik, I, Madrazo, J, Gilliland, G.L, Medved, L.
登録日2005-06-27
公開日2006-05-02
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.65 Å)
主引用文献Structural basis for sequential cleavage of fibrinopeptides upon fibrin assembly.
Biochemistry, 45, 2006
7TPP
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BU of 7tpp by Molmil
Cryo-em structure of human prothrombin:prothrombinase at 4.1 Angstrom resolution
分子名称: Activated factor Xa heavy chain, Coagulation factor Va, Factor X light chain, ...
著者Di Cera, E, Ruben, E.A.
登録日2022-01-25
公開日2022-05-04
最終更新日2022-06-29
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Cryo-EM structure of the prothrombin-prothrombinase complex.
Blood, 139, 2022
6C2W
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BU of 6c2w by Molmil
Crystal structure of human prothrombin mutant S101C/A470C
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Prothrombin, ...
著者Chinnaraj, M, Chen, Z, Pelc, L, Grese, Z, Bystranowska, D, Di Cera, E, Pozzi, N.
登録日2018-01-09
公開日2018-02-28
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (4.12 Å)
主引用文献Structure of prothrombin in the closed form reveals new details on the mechanism of activation.
Sci Rep, 8, 2018
6BJR
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BU of 6bjr by Molmil
Crystal structure of prothrombin mutant S101C/A470C
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Prothrombin, ...
著者Chinnaraj, M, Chen, Z, Pelc, L, Grese, Z, Bystranowska, D, Di Cera, E, Pozzi, N.
登録日2017-11-06
公開日2018-06-27
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (6 Å)
主引用文献Structure of prothrombin in the closed form reveals new details on the mechanism of activation.
Sci Rep, 8, 2018
1AYK
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INHIBITOR-FREE CATALYTIC FRAGMENT OF HUMAN FIBROBLAST COLLAGENASE, NMR, 30 STRUCTURES
分子名称: CALCIUM ION, COLLAGENASE, ZINC ION
著者Powers, R, Moy, F.J.
登録日1997-11-06
公開日1998-02-25
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献High-resolution solution structure of the inhibitor-free catalytic fragment of human fibroblast collagenase determined by multidimensional NMR.
Biochemistry, 37, 1998
4AYK
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CATALYTIC FRAGMENT OF HUMAN FIBROBLAST COLLAGENASE COMPLEXED WITH CGS-27023A, NMR, 30 STRUCTURES
分子名称: CALCIUM ION, N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE, PROTEIN (COLLAGENASE), ...
著者Powers, R, Moy, F.J.
登録日1999-02-01
公開日1999-06-05
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献NMR solution structure of the catalytic fragment of human fibroblast collagenase complexed with a sulfonamide derivative of a hydroxamic acid compound.
Biochemistry, 38, 1999

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