6P9U

Crystal structure of human thrombin mutant W215A

Summary for 6P9U

• Entry DOI: 10.2210/pdb6p9u/pdb
• Related: 1SHH
• Descriptor: Prothrombin, ZINC ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: trypsin-like protease, allosteric equilibrium, closed and open conformations, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 141170.61

Authors

Pelc, L.A.,Koester, S.K.,Chen, Z.,Di Cera, E. (deposition date: 2019-06-10, release date: 2019-09-04, Last modification date: 2023-10-11)

• Primary citation: Pelc, L.A.,Koester, S.K.,Chen, Z.,Gistover, N.E.,Di Cera, E.; Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin.; Sci Rep, 9:12304-12304, 2019; PubMed: 31444378; DOI: 10.1038/s41598-019-48839-1

Experimental method

X-RAY DIFFRACTION (3.3 Å)