6P9U
Crystal structure of human thrombin mutant W215A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, E, G | Prothrombin | polymer | 31 | 3647.1 | 4 | UniProt (P00734) Pfam (PF09396) In PDB | Homo sapiens (Human) | Coagulation factor II |
2 | B, D, F, H | Prothrombin | polymer | 273 | 31309.9 | 4 | UniProt (P00734) Pfam (PF00089) In PDB | Homo sapiens (Human) | Coagulation factor II |
3 | B, C, D, E, F... | ZINC ION | non-polymer | 65.4 | 7 | Chemie (ZN) | |||
4 | B, D, F, H | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
5 | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
B, D, F, H: 16 - 247 (UniProt: P00734)
PDB | External Database | Details |
---|---|---|
Ala 215 | Trp 590 | engineered mutation |
Tyr 248 | - | expression tag |
Leu 249 | - | expression tag |
Glu 250 | - | expression tag |
Asp 251 | - | expression tag |
Gln 252 | - | expression tag |
Val 253 | - | expression tag |
Asp 254 | - | expression tag |
Pro 255 | - | expression tag |
Arg 256 | - | expression tag |
Leu 257 | - | expression tag |
Ile 258 | - | expression tag |
Asp 259 | - | expression tag |
Gly 260 | - | expression tag |
Lys 261 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 139827.9 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 1342.7 | |
All* | Total formula weight | 141170.6 |