3PMH
Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct alpha-Thrombin Sites
Summary for 3PMH
Entry DOI | 10.2210/pdb3pmh/pdb |
Related | 1OOK |
Related PRD ID | PRD_000021 |
Descriptor | THROMBIN ALPHA-CHAIN, THROMBIN BETA-CHAIN, Platelet glycoprotein Ib alpha chain, ... (6 entities in total) |
Functional Keywords | sulfated tyrosine residues, leucine rich repeats, protease platelet receptor of thrombin, thrombin binding, platelet surface, blood cloting, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 68006.73 |
Authors | Varughese, K.I.,Celikel, R. (deposition date: 2010-11-16, release date: 2011-06-01, Last modification date: 2023-12-06) |
Primary citation | Zarpellon, A.,Celikel, R.,Roberts, J.R.,McClintock, R.A.,Mendolicchio, G.L.,Moore, K.L.,Jing, H.,Varughese, K.I.,Ruggeri, Z.M. Binding of alpha-thrombin to surface-anchored platelet glycoprotein Ib(alpha) sulfotyrosines through a two-site mechanism involving exosite I. Proc.Natl.Acad.Sci.USA, 108:8628-8633, 2011 Cited by PubMed: 21555542DOI: 10.1073/pnas.1017042108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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