4O03

Crystal structure of Ca2+ bound prothrombin deletion mutant residues 146-167

Summary for 4O03

• Entry DOI: 10.2210/pdb4o03/pdb
• Related: 1NL1 4NZQ
• Descriptor: Prothrombin, CALCIUM ION, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: prothrombin, kringle, serine protease, coagulation, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 64421.68

Authors

Pozzi, N.,Chen, Z.,Shropshire, D.B.,Pelc, L.A.,Di Cera, E. (deposition date: 2013-12-13, release date: 2014-05-21, Last modification date: 2023-12-06)

• Primary citation: Pozzi, N.,Chen, Z.,Pelc, L.A.,Shropshire, D.B.,Di Cera, E.; The linker connecting the two kringles plays a key role in prothrombin activation.; Proc.Natl.Acad.Sci.USA, 111:7630-7635, 2014; PubMed: 24821807; DOI: 10.1073/pnas.1403779111

Experimental method

X-RAY DIFFRACTION (3.38 Å)