7NTU

X-ray structure of the complex between human alpha thrombin and two duplex/quadruplex aptamers: NU172 and HD22_27mer

Summary for 7NTU

• Entry DOI: 10.2210/pdb7ntu/pdb
• Related PRD ID: PRD_000020
• Descriptor: Prothrombin, NU172, HD22_27mer, ... (8 entities in total)
• Functional Keywords: ternary complex, anticoagulant aptamers, duplex/quadruplex, coagulation factor, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 102511.16

Authors

Troisi, R.,Santamaria, A.,Sica, F. (deposition date: 2021-03-10, release date: 2021-04-28, Last modification date: 2024-01-31)

• Primary citation: Troisi, R.,Balasco, N.,Santamaria, A.,Vitagliano, L.,Sica, F.; Structural and functional analysis of the simultaneous binding of two duplex/quadruplex aptamers to human alpha-thrombin.; Int.J.Biol.Macromol., 181:858-867, 2021; PubMed: 33864869; DOI: 10.1016/j.ijbiomac.2021.04.076

Experimental method

X-RAY DIFFRACTION (3.1 Å)