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1TQ9
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BU of 1tq9 by Molmil
Non-covalent swapped dimer of Bovine Seminal Ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE
Descriptor: 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE, Ribonuclease, seminal
Authors:Sica, F, Di Fiore, A, Merlino, A, Mazzarella, L.
Deposit date:2004-06-17
Release date:2004-09-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and Stability of the Non-covalent Swapped Dimer of Bovine Seminal Ribonuclease: AN ENZYME TAILORED TO EVADE RIBONUCLEASE PROTEIN INHIBITOR
J.Biol.Chem., 279, 2004
1N3Z
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BU of 1n3z by Molmil
Crystal structure of the [S-carboxyamidomethyl-Cys31, S-carboxyamidomethyl-Cys32] monomeric derivative of the bovine seminal ribonuclease in the liganded state
Descriptor: 3'-URIDINEMONOPHOSPHATE, ADENOSINE, Ribonuclease, ...
Authors:Sica, F, Di Fiore, A, Zagari, A, Mazzarella, L.
Deposit date:2002-10-30
Release date:2003-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative
Proteins, 52, 2003
1N1X
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BU of 1n1x by Molmil
Crystal Structure Analysis of the monomeric [S-carboxyamidomethyl-Cys31, S-carboxyamidomethyl-Cys32] Bovine seminal ribonuclease
Descriptor: Ribonuclease, seminal
Authors:Sica, F, Di Fiore, A, Zagari, A, Mazzarella, L.
Deposit date:2002-10-21
Release date:2003-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative
Proteins, 52, 2003
7BFL
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BU of 7bfl by Molmil
X-ray structure of SS-RNase-2 des116-120
Descriptor: Angiogenin-1
Authors:Sica, F, Russo Krauss, I, Troisi, R.
Deposit date:2021-01-04
Release date:2021-04-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:The structural features of an ancient ribonuclease from Salmo salar reveal an intriguing case of auto-inhibition.
Int.J.Biol.Macromol., 182, 2021
7BFK
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BU of 7bfk by Molmil
X-ray structure of SS-RNase-2
Descriptor: Angiogenin-1
Authors:Sica, F, Russo Krauss, I, Troisi, R.
Deposit date:2021-01-04
Release date:2021-04-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:The structural features of an ancient ribonuclease from Salmo salar reveal an intriguing case of auto-inhibition.
Int.J.Biol.Macromol., 182, 2021
2P1X
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BU of 2p1x by Molmil
Crystal structure analysis of the complex between CyaY and Eu(III)
Descriptor: EUROPIUM (III) ION, Protein cyaY
Authors:Sica, F, Franzese, M.
Deposit date:2007-03-06
Release date:2007-10-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Understanding the binding properties of an unusual metal-binding protein-a study of bacterial frataxin
Febs J., 274, 2007
2EFF
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BU of 2eff by Molmil
Crystal structure analysis of the complex between CyaY and Co(II)
Descriptor: COBALT (II) ION, Protein cyaY
Authors:Sica, F, Franzese, M.
Deposit date:2007-02-22
Release date:2007-10-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Understanding the binding properties of an unusual metal-binding protein - a study of bacterial frataxin
Febs J., 274, 2007
4N4C
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BU of 4n4c by Molmil
Crystal structure of the C-terminal swapped dimer of a Bovine seminal ribonuclease mutant
Descriptor: PHOSPHATE ION, Seminal ribonuclease
Authors:Pica, A, Russo Krauss, I, Merlino, A, Sica, F.
Deposit date:2013-10-08
Release date:2013-11-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:The multiple forms of bovine seminal ribonuclease: Structure and stability of a C-terminal swapped dimer.
Febs Lett., 587, 2013
11BG
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BU of 11bg by Molmil
A POTENTIAL ALLOSTERIC SUBSITE GENERATED BY DOMAIN SWAPPING IN BOVINE SEMINAL RIBONUCLEASE
Descriptor: PROTEIN (BOVINE SEMINAL RIBONUCLEASE), SULFATE ION, URIDYLYL-2'-5'-PHOSPHO-GUANOSINE
Authors:Vitagliano, L, Adinolfi, S, Sica, F, Merlino, A, Zagari, A, Mazzarella, L.
Deposit date:1999-03-11
Release date:1999-11-05
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A potential allosteric subsite generated by domain swapping in bovine seminal ribonuclease.
J.Mol.Biol., 293, 1999
11BA
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BU of 11ba by Molmil
BINDING OF A SUBSTRATE ANALOGUE TO A DOMAIN SWAPPING PROTEIN IN THE COMPLEX OF BOVINE SEMINAL RIBONUCLEASE WITH URIDYLYL-2',5'-ADENOSINE
Descriptor: PROTEIN (RIBONUCLEASE, SEMINAL), SULFATE ION, ...
Authors:Vitagliano, L, Adinolfi, S, Riccio, A, Sica, F, Zagari, A, Mazzarella, L.
Deposit date:1999-03-17
Release date:1999-03-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Binding of a substrate analog to a domain swapping protein: X-ray structure of the complex of bovine seminal ribonuclease with uridylyl(2',5')adenosine.
Protein Sci., 7, 1998
7ZKN
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BU of 7zkn by Molmil
X-ray structure of the complex between human alpha thrombin and a pseudo-cyclic thrombin binding aptamer (TBA-NNp/DDp) - Crystal form gamma
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[13-methyl-5,7,12,14-tetrakis(oxidanylidene)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(15),2,4(16),8,10-pentaen-6-yl]propyl 3-[5,7,12,14-tetrakis(oxidanylidene)-13-(3-oxidanylpropyl)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1,3,8(16),9,11(15)-pentaen-6-yl]propyl hydrogen phosphate, 3-[5-[3-bis(oxidanyl)phosphanyloxypropoxy]naphthalen-1-yl]oxypropyl 3-(5-oxidanylnaphthalen-1-yl)oxypropyl hydrogen phosphate, ...
Authors:Troisi, R, Sica, F.
Deposit date:2022-04-13
Release date:2022-11-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers.
Mol Ther Nucleic Acids, 30, 2022
7ZKL
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BU of 7zkl by Molmil
X-ray structure of the complex between human alpha thrombin and a pseudo-cyclic thrombin binding aptamer (TBA-NNp/DDp) - Crystal form alpha
Descriptor: (2S)-2-hydroxybutanedioic acid, 3-[13-methyl-5,7,12,14-tetrakis(oxidanylidene)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(15),2,4(16),8,10-pentaen-6-yl]propyl 3-[5,7,12,14-tetrakis(oxidanylidene)-13-(3-oxidanylpropyl)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1,3,8(16),9,11(15)-pentaen-6-yl]propyl hydrogen phosphate, 3-[5-[3-bis(oxidanyl)phosphanyloxypropoxy]naphthalen-1-yl]oxypropyl 3-(5-oxidanylnaphthalen-1-yl)oxypropyl hydrogen phosphate, ...
Authors:Troisi, R, Sica, F.
Deposit date:2022-04-13
Release date:2022-11-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers.
Mol Ther Nucleic Acids, 30, 2022
7ZKO
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BU of 7zko by Molmil
X-ray structure of the complex between human alpha thrombin and a pseudo-cyclic thrombin binding aptamer (TBA-NNp/DDp) - Crystal form delta
Descriptor: 3-[13-methyl-5,7,12,14-tetrakis(oxidanylidene)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(15),2,4(16),8,10-pentaen-6-yl]propyl 3-[5,7,12,14-tetrakis(oxidanylidene)-13-(3-oxidanylpropyl)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1,3,8(16),9,11(15)-pentaen-6-yl]propyl hydrogen phosphate, 3-[5-[3-bis(oxidanyl)phosphanyloxypropoxy]naphthalen-1-yl]oxypropyl 3-(5-oxidanylnaphthalen-1-yl)oxypropyl hydrogen phosphate, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ...
Authors:Troisi, R, Sica, F.
Deposit date:2022-04-13
Release date:2022-11-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers.
Mol Ther Nucleic Acids, 30, 2022
7ZKM
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BU of 7zkm by Molmil
X-ray structure of the complex between human alpha thrombin and a pseudo-cyclic thrombin binding aptamer (TBA-NNp/DDp) - Crystal form beta
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[13-methyl-5,7,12,14-tetrakis(oxidanylidene)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(15),2,4(16),8,10-pentaen-6-yl]propyl 3-[5,7,12,14-tetrakis(oxidanylidene)-13-(3-oxidanylpropyl)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1,3,8(16),9,11(15)-pentaen-6-yl]propyl hydrogen phosphate, 3-[5-[3-bis(oxidanyl)phosphanyloxypropoxy]naphthalen-1-yl]oxypropyl 3-(5-oxidanylnaphthalen-1-yl)oxypropyl hydrogen phosphate, ...
Authors:Troisi, R, Sica, F.
Deposit date:2022-04-13
Release date:2022-11-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers.
Mol Ther Nucleic Acids, 30, 2022
4I7Y
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BU of 4i7y by Molmil
Crystal Structure of Human Alpha Thrombin in Complex with a 27-mer Aptamer Bound to Exosite II
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, DNA (27-MER), ...
Authors:Pica, A, Russo Krauss, I, Merlino, A, Mazzarella, L, Sica, F.
Deposit date:2012-12-01
Release date:2013-10-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Duplex-quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamer.
Acta Crystallogr.,Sect.D, 69, 2013
1Y92
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BU of 1y92 by Molmil
Crystal structure of the P19A/N67D Variant Of Bovine seminal Ribonuclease
Descriptor: Seminal ribonuclease
Authors:Picone, D, Di Fiore, A, Ercole, C, Franzese, M, Sica, F, Tomaselli, S, Mazzarella, L.
Deposit date:2004-12-14
Release date:2004-12-28
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Role of the Hinge Loop in Domain Swapping: THE SPECIAL CASE OF BOVINE SEMINAL RIBONUCLEASE.
J.Biol.Chem., 280, 2005
1Y94
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BU of 1y94 by Molmil
Crystal structure of the G16S/N17T/P19A/S20A/N67D Variant Of Bovine seminal Ribonuclease
Descriptor: Seminal ribonuclease
Authors:Picone, D, Di Fiore, A, Ercole, C, Franzese, M, Sica, F, Tomaselli, S, Mazzarella, L.
Deposit date:2004-12-14
Release date:2004-12-28
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Role of the Hinge Loop in Domain Swapping: THE SPECIAL CASE OF BOVINE SEMINAL RIBONUCLEASE.
J.Biol.Chem., 280, 2005
3BCP
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BU of 3bcp by Molmil
Crystal Structure of The Swapped non covalent form of P19A/L28Q/N67D BS-RNase
Descriptor: Seminal ribonuclease
Authors:Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F.
Deposit date:2007-11-13
Release date:2008-02-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme
J.Mol.Biol., 376, 2008
3BCM
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BU of 3bcm by Molmil
Crystal Structure of The Unswapped Form of P19A/L28Q/N67D BS-RNase
Descriptor: PHOSPHATE ION, Seminal ribonuclease
Authors:Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F.
Deposit date:2007-11-13
Release date:2008-02-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme
J.Mol.Biol., 376, 2008
3BCO
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BU of 3bco by Molmil
Crystal Structure of The Swapped FOrm of P19A/L28Q/N67D BS-RNase
Descriptor: Seminal ribonuclease
Authors:Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F.
Deposit date:2007-11-13
Release date:2008-02-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme
J.Mol.Biol., 376, 2008
6Z8W
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BU of 6z8w by Molmil
X-ray structure of the complex between human alpha thrombin and a thrombin binding aptamer variant (TBA-3G), which contains 1-beta-D-glucopyranosyl residue in the side chain of Thy3 at N3.
Descriptor: D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, POTASSIUM ION, Prothrombin, ...
Authors:Troisi, R, Timofeev, E.N, Sica, F.
Deposit date:2020-06-02
Release date:2021-01-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12.
Mol Ther Nucleic Acids, 23, 2021
7NTU
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BU of 7ntu by Molmil
X-ray structure of the complex between human alpha thrombin and two duplex/quadruplex aptamers: NU172 and HD22_27mer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, HD22_27mer, ...
Authors:Troisi, R, Santamaria, A, Sica, F.
Deposit date:2021-03-10
Release date:2021-04-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural and functional analysis of the simultaneous binding of two duplex/quadruplex aptamers to human alpha-thrombin.
Int.J.Biol.Macromol., 181, 2021
4YIP
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BU of 4yip by Molmil
X-ray structure of the iron/manganese cambialistic superoxide dismutase from Streptococcus mutans
Descriptor: FE (III) ION, Superoxide dismutase [Mn/Fe]
Authors:Russo Krauss, I, Merlino, A, Pica, A, Sica, F.
Deposit date:2015-03-02
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Fine tuning of metal-specific activity in the Mn-like group of cambialistic superoxide dismutases
Rsc Adv, 5, 2015
4YIO
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BU of 4yio by Molmil
X-ray structure of the iron/manganese cambialistic superoxide dismutase from Streptococcus thermophilus
Descriptor: FE (III) ION, GLYCEROL, SULFATE ION, ...
Authors:Russo Krauss, I, Merlino, A, Pica, A, Sica, F.
Deposit date:2015-03-02
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Fine tuning of metal-specific activity in the Mn-like group of cambialistic superoxide dismutases
Rsc Adv, 5, 2015
5EW1
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BU of 5ew1 by Molmil
Human thrombin sandwiched between two DNA aptamers: HD22 and HD1-deltaT3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, HD1-deltaT3, ...
Authors:Pica, A, Russo Krauss, I, Parente, V, Sica, F.
Deposit date:2015-11-20
Release date:2016-11-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers.
Nucleic Acids Res., 45, 2017

 

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