7NTU
X-ray structure of the complex between human alpha thrombin and two duplex/quadruplex aptamers: NU172 and HD22_27mer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Prothrombin | polymer | 36 | 4096.5 | 2 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (Human) | Coagulation factor II |
| 2 | B, D (B, D) | Prothrombin | polymer | 259 | 29780.2 | 2 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (Human) | Coagulation factor II |
| 3 | E, G (E, G) | NU172 | polymer | 26 | 8172.2 | 2 | synthetic construct | ||
| 4 | F, H (F, I) | HD22_27mer | polymer | 27 | 8485.4 | 2 | synthetic construct | ||
| 5 | I, K (B, D) | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide | non-polymer | 454.0 | 2 | BIRD (PRD_000020) Chemie (0G6) | |||
| 6 | J, L (B, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 7 | M, N, O, P (E, F, G, I) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 8 | Q, R, S, T, U... (A, B, C, D, E...) | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 101068.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1442.3 | |
| All* | Total formula weight | 102511.2 |
