4E06

Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism

Summary for 4E06
Related4E05
DescriptorThrombin, Salivary anti-thrombin peptide anophelin, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceAnopheles albimanus (New world malaria mosquito)
More
Total number of polymer chains3
Total formula weight40663.65
Authors
Figueiredo, A.C.,de Sanctis, D.,Gutierrez-Gallego, R.,Cereija, T.B.,Macedo-Ribeiro, S.,Fuentes-Prior, P.,Pereira, P.J.B. (deposition date: 2012-03-02, release date: 2012-12-05, Last modification date: 2020-07-29)
Primary citationCereija, T.B.,Figueiredo, A.C.,Fuentes-Prior, P.,Gutierrez-Gallego, R.,Macedo-Ribeiro, S.,Pereira, P.J.,de Sanctis, D.
Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector.
Proc.Natl.Acad.Sci.USA, 109:E3649-E3658, 2012
PubMed: 23223529
DOI: 110.1073/pnas.1211614109
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.196 Å)
Structure validation
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PDB entries from 2021-06-23