7ZKL

X-ray structure of the complex between human alpha thrombin and a pseudo-cyclic thrombin binding aptamer (TBA-NNp/DDp) - Crystal form alpha

Summary for 7ZKL

• Entry DOI: 10.2210/pdb7zkl/pdb
• Related: 7ZKM 7ZKN 7ZKO
• Descriptor: Thrombin light chain, Thrombin heavy chain, TBA-NNp/DDp, ... (10 entities in total)
• Functional Keywords: thrombin, aptamer, complex, inhibitor, coagulation, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 40935.22

Authors

Troisi, R.,Sica, F. (deposition date: 2022-04-13, release date: 2022-11-30, Last modification date: 2024-01-31)

• Primary citation: Troisi, R.,Riccardi, C.,Perez de Carvasal, K.,Smietana, M.,Morvan, F.,Del Vecchio, P.,Montesarchio, D.,Sica, F.; A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers.; Mol Ther Nucleic Acids, 30:585-594, 2022; PubMed: 36457701; DOI: 10.1016/j.omtn.2022.11.007

Experimental method

X-RAY DIFFRACTION (3.18 Å)