7ZKM
X-ray structure of the complex between human alpha thrombin and a pseudo-cyclic thrombin binding aptamer (TBA-NNp/DDp) - Crystal form beta
Summary for 7ZKM
Entry DOI | 10.2210/pdb7zkm/pdb |
Related | 7ZKL 7ZKN 7ZKO |
Descriptor | Thrombin light chain, Thrombin heavy chain, TBA-NNp/DDp, ... (10 entities in total) |
Functional Keywords | thrombin, aptamer, complex, inhibitor, coagulation, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 47672.94 |
Authors | Troisi, R.,Sica, F. (deposition date: 2022-04-13, release date: 2022-11-30, Last modification date: 2024-01-31) |
Primary citation | Troisi, R.,Riccardi, C.,Perez de Carvasal, K.,Smietana, M.,Morvan, F.,Del Vecchio, P.,Montesarchio, D.,Sica, F. A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers. Mol Ther Nucleic Acids, 30:585-594, 2022 Cited by PubMed: 36457701DOI: 10.1016/j.omtn.2022.11.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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