7ZKM

X-ray structure of the complex between human alpha thrombin and a pseudo-cyclic thrombin binding aptamer (TBA-NNp/DDp) - Crystal form beta

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	L	Thrombin light chain	polymer	36	4096.5	1	UniProt (P00734) Pfam (PF09396) In PDB	Homo sapiens (human)
2	H	Thrombin heavy chain	polymer	259	29780.2	1	UniProt (P00734) Pfam (PF00089) In PDB	Homo sapiens (human)
3	A, B	TBA-NNp/DDp	polymer	15	4743.1	2		synthetic construct
4	C	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	H	D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide	non-polymer		454.0	1	Chemie (0G6)
6	H	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
7	A, B	3-[13-methyl-5,7,12,14-tetrakis(oxidanylidene)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(15),2,4(16),8,10-pentaen-6-yl]propyl 3-[5,7,12,14-tetrakis(oxidanylidene)-13-(3-oxidanylpropyl)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1,3,8(16),9,11(15)-pentaen-6-yl]propyl hydrogen phosphate	non-polymer		1044.7	2	Chemie (JL0)
8	A, B	3-[5-[3-bis(oxidanyl)phosphanyloxypropoxy]naphthalen-1-yl]oxypropyl 3-(5-oxidanylnaphthalen-1-yl)oxypropyl hydrogen phosphate	non-polymer		620.5	2	Chemie (JKR)
9	A, B	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
10		water	water		18.0	44	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	43362.9
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	8
	Total formula weight	3885.7
All*	Total formula weight	47672.9

*Water molecules are not included.