1DWB

CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS

Summary for 1DWB

Entry DOI	10.2210/pdb1dwb/pdb
Related	1DWC 1DWD 1DWE
Descriptor	ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUDIN IIIA, ... (5 entities in total)
Functional Keywords	serine proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P00734 P00734 Secreted: P28508
Total number of polymer chains	3
Total formula weight	35408.37
Authors	Banner, D.W.,Hadvary, P. (deposition date: 1992-08-19, release date: 1994-01-31, Last modification date: 2011-07-13)
Primary citation	Banner, D.W.,Hadvary, P. Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266:20085-20093, 1991 Cited by PubMed: 1939071 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.16 Å)

Structure validation