8UF7
Cryo-EM structure of POmAb, a Type-I anti-prothrombin antiphospholipid antibody, bound to kringle-1 of human prothrombin
Summary for 8UF7
| Entry DOI | 10.2210/pdb8uf7/pdb |
| EMDB information | 42185 |
| Descriptor | POmAb Light Chain, POmAb Heavy Chain, Prothrombin (3 entities in total) |
| Functional Keywords | autoimmunity, thrombosis, complex, immunoglobulin, coagulation factor, anticoagulation, inhibitor, blood clotting |
| Biological source | Mus musculus (mouse) More |
| Total number of polymer chains | 3 |
| Total formula weight | 112350.52 |
| Authors | Kumar, S.,Summers, B.,Basore, K.,Pozzi, N. (deposition date: 2023-10-03, release date: 2024-02-14, Last modification date: 2024-03-27) |
| Primary citation | Kumar, S.,Summers, B.,Basore, K.,Pengo, V.,Flaumenhaft, R.,Pozzi, N. Cryo-EM structure and functional basis of prothrombin recognition by a Type-I anti-prothrombin antiphospholipid antibody. Blood, 2024 Cited by PubMed: 38437497DOI: 10.1182/blood.2023022942 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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