8UF7

Cryo-EM structure of POmAb, a Type-I anti-prothrombin antiphospholipid antibody, bound to kringle-1 of human prothrombin

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0001530	molecular_function	lipopolysaccharide binding
C	0004175	molecular_function	endopeptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005102	molecular_function	signaling receptor binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0005796	cellular_component	Golgi lumen
C	0005886	cellular_component	plasma membrane
C	0006508	biological_process	proteolysis
C	0006953	biological_process	acute-phase response
C	0007166	biological_process	cell surface receptor signaling pathway
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007596	biological_process	blood coagulation
C	0007599	biological_process	hemostasis
C	0008083	molecular_function	growth factor activity
C	0008201	molecular_function	heparin binding
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0009611	biological_process	response to wounding
C	0009897	cellular_component	external side of plasma membrane
C	0010544	biological_process	negative regulation of platelet activation
C	0016787	molecular_function	hydrolase activity
C	0030168	biological_process	platelet activation
C	0030193	biological_process	regulation of blood coagulation
C	0030194	biological_process	positive regulation of blood coagulation
C	0030195	biological_process	negative regulation of blood coagulation
C	0031012	cellular_component	extracellular matrix
C	0032967	biological_process	positive regulation of collagen biosynthetic process
C	0042730	biological_process	fibrinolysis
C	0045861	biological_process	negative regulation of proteolysis
C	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
C	0048018	molecular_function	receptor ligand activity
C	0048712	biological_process	negative regulation of astrocyte differentiation
C	0050878	biological_process	regulation of body fluid levels
C	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
C	0051480	biological_process	regulation of cytosolic calcium ion concentration
C	0051918	biological_process	negative regulation of fibrinolysis
C	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
C	0070053	molecular_function	thrombospondin receptor activity
C	0070062	cellular_component	extracellular exosome
C	0070493	biological_process	thrombin-activated receptor signaling pathway
C	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
C	0072562	cellular_component	blood microparticle
C	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
C	1900182	biological_process	positive regulation of protein localization to nucleus
C	1900738	biological_process	positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
C	2000379	biological_process	positive regulation of reactive oxygen species metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00011
Number of Residues	26
Details	GLA_1 Vitamin K-dependent carboxylation domain. EcvEEtCsyeeafEalesstatdv.FW

Chain	Residue	Details
C	GLU16-TRP41

---

site_id	PS00021
Number of Residues	14
Details	KRINGLE_1 Kringle domain signature. FCRNpdssttgpWC

Chain	Residue	Details
C	PHE113-CYS126
C	PHE218-CYS231

---

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
C	LEU359-CYS364

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV

Chain	Residue	Details
C	ASP519-VAL530

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
A	TYR193-HIS199

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	78
Details	Domain: {"description":"Kringle 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00121","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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