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PDB: 52 件
8UKY
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BU of 8uky by Molmil
Crystal structure of BAK in complex with inhibiting antibody 14G6
分子名称: 1,2-ETHANEDIOL, 14G6 Fab heavy chain, 14G6 Fab light chain, ...
著者Miller, M.S, Czabotar, P.E.
登録日2023-10-15
公開日2024-04-10
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (2.398 Å)
主引用文献A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells.
Cell Death Differ., 31, 2024
1BXL
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BU of 1bxl by Molmil
STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称: BAK PEPTIDE, BCL-XL
著者Sattler, M, Liang, H, Nettesheim, D, Meadows, R.P, Harlan, J.E, Eberstadt, M, Yoon, H, Shuker, S.B, Chang, B.S, Minn, A.J, Thompson, C.B, Fesik, S.W.
登録日1996-10-16
公開日1997-10-29
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.
Science, 275, 1997
6ODH
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BU of 6odh by Molmil
BH3 domain swapped dimer of a BAK fragment
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Bcl-2 homologous antagonist/killer, DI(HYDROXYETHYL)ETHER, ...
著者Liu, L.-K.
登録日2019-03-26
公開日2020-10-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A BAK fragment that binds mitochondrial lipids and releases cytochrome c
To Be Published
8IVB
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BU of 8ivb by Molmil
K113-Ubiquitinated BAK
分子名称: Bcl-2 homologous antagonist/killer, Ubiquitin
著者Dong, X, Cheng, P, Hou, Y.Z, Chen, Y.K, Liu, Z.
登録日2023-03-26
公開日2024-01-31
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Parkin-mediated ubiquitination inhibits BAK apoptotic activity by blocking its canonical hydrophobic groove.
Commun Biol, 6, 2023
3I1H
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BU of 3i1h by Molmil
Crystal structure of human BFL-1 in complex with BAK BH3 peptide
分子名称: Apoptosis regulator BAK, Protein BFL-1
著者Guan, R, Xiao, R, Zhao, L, Acton, T, White, E, Gelinas, C, Montelione, G.T, Northeast Structural Genomics Consortium (NESG)
登録日2009-06-26
公開日2009-07-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献crystal structure of human BFL-1 in complex with BAK BH3 peptide
To be Published
3QBR
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BU of 3qbr by Molmil
BakBH3 in complex with sjA
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Bcl-2 homologous antagonist/killer, SJCHGC06286 protein
著者Lee, E.F, Clarke, O.B, Fairlie, W.D, Colman, P.M, Evangelista, M, Feng, Z, Speed, T.P, Tchoubrieva, E, Strasser, A, Kalinna, B.
登録日2011-01-13
公開日2011-04-13
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.601 Å)
主引用文献Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes.
Proc.Natl.Acad.Sci.USA, 108, 2011
5AJK
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BU of 5ajk by Molmil
Crystal structure of variola virus virulence factor F1L in complex with human Bak BH3 domain
分子名称: ACETATE ION, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, CHLORIDE ION, ...
著者Kvansakul, M, Colman, P.M.
登録日2015-02-25
公開日2015-03-25
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Variola Virus F1L is a Bcl-2-Like Protein that Unlike its Vaccinia Virus Counterpart Inhibits Apoptosis Independent of Bim.
Cell Death Dis., 6, 2015
4D2L
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BU of 4d2l by Molmil
Vaccinia Virus F1L bound to Bak BH3
分子名称: BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, PROTEIN F1L
著者Kvansakul, M, Colman, P.M.
登録日2014-05-12
公開日2014-06-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.903 Å)
主引用文献Structural Insight Into Bh3-Domain Binding of Vaccinia Virus Anti-Apoptotic F1L.
J.Virol., 88, 2014
2YV6
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BU of 2yv6 by Molmil
Crystal structure of human Bcl-2 family protein Bak
分子名称: Bcl-2 homologous antagonist/killer, SULFATE ION
著者Wang, H, Kishishita, S, Murayama, K, Takemoto, C, Terada, T, Shirouzu, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-04-09
公開日2008-04-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Novel dimerization mode of the human Bcl-2 family protein Bak, a mitochondrial apoptosis regulator.
J.Struct.Biol., 166, 2009
2LP8
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BU of 2lp8 by Molmil
SOLUTION STRUCTURE OF AN APOPTOSIS ACTIVATING PHOTOSWITCHABLE BAK PEPTIDE BOUND to BCL-XL
分子名称: 3,3'-(E)-diazene-1,2-diylbis{6-[(chloroacetyl)amino]benzenesulfonic acid}, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 1
著者Wysoczanski, P, Mart, R.J, Loveridge, J.E, Williams, C, Whittaker, S.B.-M, Crump, M.P, Allemann, R.K.
登録日2012-02-03
公開日2012-04-18
最終更新日2021-08-18
実験手法SOLUTION NMR
主引用文献NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-x(L).
J.Am.Chem.Soc., 134, 2012
2M5B
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BU of 2m5b by Molmil
The NMR structure of the BID-BAK complex
分子名称: Bcl-2 homologous antagonist/killer, human_BID_BH3_SAHB
著者Moldoveanu, T, Grace, C.R, Kriwacki, R.W, Green, D.R.
登録日2013-02-19
公開日2013-04-17
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献BID-induced structural changes in BAK promote apoptosis.
Nat.Struct.Mol.Biol., 20, 2013
8SRX
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BU of 8srx by Molmil
Crystal structure of BAK-BAX heterodimer with lysoPC
分子名称: 1,2-ETHANEDIOL, Apoptosis regulator BAX, Bcl-2 homologous antagonist/killer, ...
著者Brouwer, J.M, Czabotar, P.E, Colman, P.M, Miller, M.S.
登録日2023-05-07
公開日2023-12-27
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 291, 2024
8SRY
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BU of 8sry by Molmil
Crystal structure of BAK-BAX heterodimer with C12E8
分子名称: 2-(2-METHOXYETHOXY)ETHANOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, ...
著者Brouwer, J.M, Czabotar, P.E, Colman, P.M, Miller, M.S.
登録日2023-05-08
公開日2023-12-27
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 291, 2024
7OFM
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BU of 7ofm by Molmil
NMR structure of the Bak transmembrane helix in DPC micelles
分子名称: Bcl-2 homologous antagonist/killer
著者Sperl, L.E, Hagn, F.
登録日2021-05-05
公開日2021-06-23
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献High-resolution analysis of the conformational transition of pro-apoptotic Bak at the lipid membrane.
Embo J., 40, 2021
7OFO
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BU of 7ofo by Molmil
NMR structure of the Bak transmembrane helix in lipid nanodiscs
分子名称: Bcl-2 homologous antagonist/killer
著者Sperl, L.E, Hagn, F.
登録日2021-05-05
公開日2021-06-23
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献High-resolution analysis of the conformational transition of pro-apoptotic Bak at the lipid membrane.
Embo J., 40, 2021
8IGC
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BU of 8igc by Molmil
Crystal structure of Bak bound to Bnip5 BH3
分子名称: Bcl-2 homologous antagonist/killer, Protein BNIP5
著者Ku, B, Lim, D.
登録日2023-02-20
公開日2023-09-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.697 Å)
主引用文献Crystal structure of Bak bound to the BH3 domain of Bnip5, a noncanonical BH3 domain-containing protein.
Proteins, 92, 2024
2XPX
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BU of 2xpx by Molmil
Crystal structure of BHRF1:Bak BH3 complex
分子名称: 1,2-ETHANEDIOL, APOPTOSIS REGULATOR BHRF1, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, ...
著者Kvansakul, M, Huang, D.C.S, Colman, P.M.
登録日2010-08-31
公開日2011-01-26
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus Bhrf1.
Plos Pathog., 6, 2010
8GSV
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BU of 8gsv by Molmil
Crystal structure of human BAK in complex with the Pxt1 BH3 domain
分子名称: Bcl-2 homologous antagonist/killer, Peroxisomal testis-specific protein 1
著者Lim, D, Ku, B.
登録日2022-09-07
公開日2023-05-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for proapoptotic activation of Bak by the noncanonical BH3-only protein Pxt1.
Plos Biol., 21, 2023
7LK4
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BU of 7lk4 by Molmil
Crystal structure of BAK L100A in complex with activating antibody fragments
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 7D10 antibody VH fragment, 7D10 antibody VL fragment, ...
著者Robin, Y.A, Colman, P.M.
登録日2021-02-01
公開日2022-02-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the alpha 1-alpha 2 loop in BAK activation.
Cell Death Differ., 29, 2022
5FMI
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BU of 5fmi by Molmil
Human Bak Q77L
分子名称: BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, ZINC ION
著者Fairlie, W.D, Lee, E.F, Smith, B.J.
登録日2015-11-06
公開日2016-06-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.491 Å)
主引用文献Physiological Restraint of Bak by Bcl-Xl is Essential for Cell Survival.
Genes Dev., 30, 2016
5FMK
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BU of 5fmk by Molmil
Bcl-xL with Bak BH3 complex
分子名称: BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, BCL-XL, GLYCEROL
著者Fairlie, W.D, Lee, E.F, Smith, B.J, Czabotar, P.E, Colman, P.M.
登録日2015-11-06
公開日2016-06-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.731 Å)
主引用文献Physiological Restraint of Bak by Bcl-Xl is Essential for Cell Survival.
Genes Dev., 30, 2016
7K02
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BU of 7k02 by Molmil
The crystal structure of a BAK dimer activated by detergent
分子名称: Bcl-2 homologous antagonist/killer
著者Birkinshaw, R.W, Czabotar, P.E.
登録日2020-09-02
公開日2021-03-31
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structure of detergent-activated BAK dimers derived from the inert monomer.
Mol.Cell, 81, 2021
7M5B
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Crystal Structure of human BAK in complex with M3W5_BID
分子名称: BH3-interacting domain death agonist p15, Bcl-2 homologous antagonist/killer, COPPER (II) ION
著者Singh, G, Aggarwal, A, Moldoveanu, T.
登録日2021-03-23
公開日2022-01-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural basis of BAK activation in mitochondrial apoptosis initiation.
Nat Commun, 13, 2022
7M5C
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BU of 7m5c by Molmil
Crystal Structure of human BAK in complex with WT BAK BH3 peptide
分子名称: Bcl-2 homologous antagonist/killer, COPPER (II) ION, SULFATE ION
著者Singh, G, Aggarwal, A, Moldoveanu, T.
登録日2021-03-23
公開日2022-01-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.06 Å)
主引用文献Structural basis of BAK activation in mitochondrial apoptosis initiation.
Nat Commun, 13, 2022
7M5A
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BU of 7m5a by Molmil
Crystal Structure of human BAK in complex with W3W5_BID
分子名称: BH3-interacting domain death agonist p15, Bcl-2 homologous antagonist/killer
著者Singh, G, Aggarwal, A, Moldoveanu, T.
登録日2021-03-23
公開日2022-01-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis of BAK activation in mitochondrial apoptosis initiation.
Nat Commun, 13, 2022

 

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