5AJK
Crystal structure of variola virus virulence factor F1L in complex with human Bak BH3 domain
Summary for 5AJK
Entry DOI | 10.2210/pdb5ajk/pdb |
Related | 5AJJ |
Descriptor | HOMOLOG OF VACCINIA VIRUS CDS F1L, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | bcl-2, apoptosis, poxvirus, bid |
Biological source | VARIOLA VIRUS (SMALLPOX) More |
Cellular location | Mitochondrion membrane ; Single-pass membrane protein : Q16611 |
Total number of polymer chains | 12 |
Total formula weight | 135454.80 |
Authors | Kvansakul, M.,Colman, P.M. (deposition date: 2015-02-25, release date: 2015-03-25, Last modification date: 2024-01-10) |
Primary citation | Marshall, B.,Puthalakath, H.,Caria, S.,Chugh, S.,Doerflinger, M.,Colman, P.M.,Kvansakul, M. Variola Virus F1L is a Bcl-2-Like Protein that Unlike its Vaccinia Virus Counterpart Inhibits Apoptosis Independent of Bim. Cell Death Dis., 6:E1680-, 2015 Cited by PubMed: 25766319DOI: 10.1038/CDDIS.2015.52 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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