7LK4

Crystal structure of BAK L100A in complex with activating antibody fragments

Summary for 7LK4

Entry DOI	10.2210/pdb7lk4/pdb
Descriptor	Bcl-2 homologous antagonist/killer, 7D10 antibody VL fragment, 7D10 antibody VH fragment, ... (5 entities in total)
Functional Keywords	swap dimer, antibody fragments, apoptosis
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	178604.36
Authors	Robin, Y.A.,Colman, P.M. (deposition date: 2021-02-01, release date: 2022-02-09, Last modification date: 2023-10-18)
Primary citation	Robin, A.Y.,Miller, M.S.,Iyer, S.,Shi, M.X.,Wardak, A.Z.,Lio, D.,Smith, N.A.,Smith, B.J.,Birkinshaw, R.W.,Czabotar, P.E.,Kluck, R.M.,Colman, P.M. Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the alpha 1-alpha 2 loop in BAK activation. Cell Death Differ., 29:1757-1768, 2022 Cited by PubMed: 35279694 DOI: 10.1038/s41418-022-00961-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation