7LK4
Crystal structure of BAK L100A in complex with activating antibody fragments
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | P, Q, R, S | Bcl-2 homologous antagonist/killer | polymer | 164 | 18452.6 | 4 | UniProt (Q16611) Pfam (PF00452) In PDB | Homo sapiens (Human) | Apoptosis regulator BAK,Bcl-2-like protein 7,Bcl2-L-7 |
| 2 | A, C, E, G | 7D10 antibody VL fragment | polymer | 109 | 11728.9 | 4 | Rattus norvegicus | ||
| 3 | B, D, F, H | 7D10 antibody VH fragment | polymer | 129 | 14262.8 | 4 | Rattus norvegicus | ||
| 4 | A, B, C, D | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 7 | Chemie (MPD) | |||
| 5 | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
P, Q, R, S: 23 - 186 (UniProt: Q16611)
| PDB | External Database | Details |
|---|---|---|
| Ala 100 | Leu 100 | engineered mutation |
| Ser 166 | Cys 166 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 177777.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 827.2 | |
| All* | Total formula weight | 178604.4 |
