5FMK

Bcl-xL with Bak BH3 complex

Summary for 5FMK

Entry DOI	10.2210/pdb5fmk/pdb
Related	5FMI 5FMJ
Descriptor	BCL-XL, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, GLYCEROL, ... (4 entities in total)
Functional Keywords	bcl-xl, bak, bh3 domain, apoptosis, bcl-2 family
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817 Mitochondrion membrane ; Single-pass membrane protein : Q16611
Total number of polymer chains	2
Total formula weight	22143.65
Authors	Fairlie, W.D.,Lee, E.F.,Smith, B.J.,Czabotar, P.E.,Colman, P.M. (deposition date: 2015-11-06, release date: 2016-06-01, Last modification date: 2024-01-10)
Primary citation	Lee, E.F.,Grabow, S.,Chappaz, S.,Dewson, G.,Hockings, C.,Kluck, R.M.,Gray, D.H.,Witkowski, M.T.,Evangelista, M.,Pettikiriarachchi, A.,Bouillet, P.,Lane, R.M.,Czabotar, P.E.,Colman, P.M.,Smith, B.J.,Kile, B.T.,Fairlie, W.D. Physiological Restraint of Bak by Bcl-Xl is Essential for Cell Survival. Genes Dev., 30:1240-, 2016 Cited by PubMed: 27198225 DOI: 10.1101/GAD.279414.116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.731 Å)

Structure validation