PDB: 2705 resultsInfo pagesStatus searchChemie searchBIRD

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4XQR	Crystal structure of unliganded human FPPS at 2.15 angstrom resolution Descriptor: Farnesyl pyrophosphate synthase, PHOSPHATE ION Authors: Park, J, Berghuis, A.M. Deposit date: 2015-01-20 Release date: 2016-01-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal structure of unliganded human FPPS at 2.15 angstrom resolution To Be Published
5UC6	Structural insights into IL-1 alpha recognition by a naphthyl-modified aptamer that mimics IL-1RI Domain III Descriptor: DNA (5'-D(*CP*G)-R(P*(85Y))-D(P*GP*AP*G)-R(P*(85Y)P*(85Y))-D(P*A)-R(P*(85Y))-D(P*GP*GP*G)-R(P*(85Y)P*(85Y))-D(P*AP*GP*AP*G)-R(P*(85Y))-D(P*CP*GP*(ATD))-3'), Interleukin-1 alpha, MAGNESIUM ION, ... Authors: Ren, X, Pyle, A. Deposit date: 2016-12-21 Release date: 2017-10-11 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis for IL-1 alpha recognition by a modified DNA aptamer that specifically inhibits IL-1 alpha signaling. Nat Commun, 8, 2017
5BVP	The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta Descriptor: CHLORIDE ION, Canakinumab Fab light-chain, Interleukin-1 beta, ... Authors: Rondeau, J.M. Deposit date: 2015-06-05 Release date: 2015-09-02 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1 beta. Mabs, 7, 2015
5CG5	Neutron crystal structure of human farnesyl pyrophosphate synthase in complex with risedronate Descriptor: 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, Farnesyl pyrophosphate synthase, MAGNESIUM ION Authors: Yokoyama, T, Mizuguchi, M, Ostermann, A, Kusaka, K, Niimura, N, Schrader, T.E, Tanaka, I. Deposit date: 2015-07-09 Release date: 2015-10-14 Last modified: 2024-04-03 Method: NEUTRON DIFFRACTION (1.402 Å), X-RAY DIFFRACTION Cite: Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase J.Med.Chem., 58, 2015
4XQT	Crystal structure of human FPPS in complex with three magnesium ions Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION Authors: Park, J, Berghuis, A.M. Deposit date: 2015-01-20 Release date: 2016-01-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of human FPPS in complex with three magnesium ions To Be Published
4XQS	Crystal structure of human FPPS in complex with one magnesium ion Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION Authors: Park, J, Berghuis, A.M. Deposit date: 2015-01-20 Release date: 2016-01-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of human FPPS in complex with one magnesium ion To Be Published
5CG6	Neutron crystal structure of human farnesyl pyrophosphate synthase in complex with risedronate and isopentenyl pyrophosphate Descriptor: 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Farnesyl pyrophosphate synthase, ... Authors: Yokoyama, T, Mizuguchi, M, Ostermann, A, Kusaka, K, Niimura, N, Schrader, T.E, Tanaka, I. Deposit date: 2015-07-09 Release date: 2015-10-14 Last modified: 2024-04-03 Method: NEUTRON DIFFRACTION (1.7 Å), X-RAY DIFFRACTION Cite: Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase J.Med.Chem., 58, 2015
4Z5X	Glycogen phosphorylase in complex with gallic acid Descriptor: 3,4,5-trihydroxybenzoic acid, Glycogen phosphorylase, muscle form, ... Authors: Kyriakis, E, Kantsadi, L.A, Stravodimos, A.G, Chatzileontiadou, S.M.D, Leonidas, D.D. Deposit date: 2015-04-03 Release date: 2015-05-13 Last modified: 2018-03-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Natural flavonoids as antidiabetic agents. The binding of gallic and ellagic acids to glycogen phosphorylase b. Febs Lett., 589, 2015
4ZFF	Dual-acting Fab 5A12 in complex with VEGF Descriptor: Fragment antigen binding (Fab) 5A12 Heavy chain, Fragment antigen binding (Fab) 5A12 Light chain, SULFATE ION, ... Authors: Harris, S.F, Wu, P. Deposit date: 2015-04-21 Release date: 2015-07-01 Last modified: 2015-09-16 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration. J.Biol.Chem., 290, 2015
5DGS	Crystal structure of human FPPS in complex with the monophosphonate compound 15 Descriptor: Farnesyl pyrophosphate synthase, {(E)-2-[6-(acetylamino)-8-(naphthalen-1-yl)quinolin-2-yl]ethenyl}phosphonic acid Authors: Rondeau, J.M, Bourgier, E, Lehmann, S. Deposit date: 2015-08-28 Release date: 2016-07-13 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.62 Å) Cite: A General Strategy for Targeting Drugs to Bone. Angew.Chem.Int.Ed.Engl., 54, 2015
5DJP	Crystal structure of human FPPS in complex with biaryl compound 5 Descriptor: 4-(naphthalen-1-yl)-1H-indole-2-carboxylic acid, Farnesyl pyrophosphate synthase, PHOSPHATE ION Authors: Rondeau, J.M, Bourgier, E, Lehmann, S. Deposit date: 2015-09-02 Release date: 2015-09-30 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015
5DJV	Crystal structure of human FPPS in complex with biaryl compound 8e Descriptor: 8-(naphthalen-1-yl)-6-(1H-pyrrol-2-yl)quinoline-2-carboxylic acid, Farnesyl pyrophosphate synthase Authors: Rondeau, J.M, Bourgier, E, Lehmann, S. Deposit date: 2015-09-02 Release date: 2015-10-07 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015
5DJR	Crystal structure of human FPPS in complex with biaryl compound 6 Descriptor: 1H,1'H-4,4'-biindole-2-carboxylic acid, Farnesyl pyrophosphate synthase, GLYCEROL, ... Authors: Rondeau, J.M, Bourgier, E, Lehmann, S. Deposit date: 2015-09-02 Release date: 2015-09-30 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015
4YI3	Crystal structure of Gpb in complex with 4a Descriptor: DIMETHYL SULFOXIDE, Glycogen phosphorylase, muscle form, ... Authors: Kantsadi, A.L, Chatzileontiadou, D.S.M, Stravodimos, G.A, Leonidas, D.D. Deposit date: 2015-02-27 Release date: 2015-11-18 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Glycogen phosphorylase as a target for type 2 diabetes: synthetic, biochemical, structural and computational evaluation of novel N-acyl-N -( beta-D-glucopyranosyl) urea inhibitors. Curr Top Med Chem, 15, 2015
4YUA	Glycogen phosphorylase in complex with ellagic acid Descriptor: 2,3,7,8-tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione, Glycogen phosphorylase, muscle form, ... Authors: Kyriakis, E, Kantsadi, L.A, Stravodimos, A.G, Chatzileontiadou, S.M.D, Leonidas, D.D. Deposit date: 2015-03-18 Release date: 2015-05-13 Last modified: 2018-01-17 Method: X-RAY DIFFRACTION (2 Å) Cite: Natural flavonoids as antidiabetic agents. The binding of gallic and ellagic acids to glycogen phosphorylase b. Febs Lett., 589, 2015
5E8H	Crystal structure of geranylfarnesyl pyrophosphate synthases 2 from Arabidopsis thaliana Descriptor: Geranylgeranyl pyrophosphate synthase 3, chloroplastic Authors: Wang, C, Chen, Q, Wang, G, Zhang, P. Deposit date: 2015-10-14 Release date: 2015-11-11 Last modified: 2019-12-25 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Analyses of Short-Chain Prenyltransferases Identify an Evolutionarily Conserved GFPPS Clade in Brassicaceae Plants. Mol Plant, 9, 2016
5DGN	Crystal structure of human FPPS in complex with compound 13 Descriptor: 8-(naphthalen-1-yl)quinoline-2-carboxylic acid, Farnesyl pyrophosphate synthase Authors: Rondeau, J.M, Bourgier, E, Lehmann, S. Deposit date: 2015-08-28 Release date: 2015-09-30 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015
4XFS	Structure of IL-18 SER Mutant I Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, Interleukin-18 Authors: Krumm, B.E, Meng, X, Xiang, Y, Deng, J. Deposit date: 2014-12-28 Release date: 2015-06-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
5DGM	Crystal structure of human FPPS in complex with monophosphonate compound 7 Descriptor: Farnesyl pyrophosphate synthase, PHOSPHATE ION, {2-[(phosphonomethyl)carbamoyl]-1H-benzo[g]indol-1-yl}acetic acid Authors: Rondeau, J.M, Bourgier, E, Lehmann, S. Deposit date: 2015-08-28 Release date: 2016-07-13 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.86 Å) Cite: A General Strategy for Targeting Drugs to Bone. Angew.Chem.Int.Ed.Engl., 54, 2015
5DIQ	Crystal structure of human FPPS in complex with salicylic acid derivative 3a Descriptor: 2-(naphthalen-1-ylmethoxy)benzoic acid, Farnesyl pyrophosphate synthase, GLYCEROL, ... Authors: Rondeau, J.M, Bourgier, E, Lehmann, S. Deposit date: 2015-09-01 Release date: 2015-09-30 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015
5ERO	Crystal structure of elongation domain of Phomopsis amygdali fusicoccadiene synthase complexed with cobalt ions and pamidronate Descriptor: COBALT (II) ION, Fusicoccadiene synthase, PAMIDRONATE Authors: Chen, M, Christianson, D.W. Deposit date: 2015-11-14 Release date: 2016-01-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase. Acs Chem.Biol., 11, 2016
5ERN	Crystal structure of elongation domain of Phomopsis amygdali fusicoccadiene synthase Descriptor: Fusicoccadiene synthase Authors: Chen, M, Christianson, D.W. Deposit date: 2015-11-14 Release date: 2016-01-20 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.434 Å) Cite: Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase. Acs Chem.Biol., 11, 2016
5AFX	T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-1238 Descriptor: FARNESYL PYROPHOSPHATE SYNTHASE, MAGNESIUM ION, [1-hydroxy-2-(1-nonyl-1H-3lambda~5~-imidazol-3-yl)ethane-1,1-diyl]bis(phosphonic acid) Authors: Yang, G, Oldfield, E, No, J.H. Deposit date: 2015-01-27 Release date: 2015-10-28 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation. Antimicrob.Agents Chemother., 59, 2015
5AHU	T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-1326 Descriptor: FARNESYL PYROPHOSPHATE SYNTHASE, PUTATIVE, MAGNESIUM ION, ... Authors: Yang, G, Oldfield, E, No, J.H. Deposit date: 2015-02-09 Release date: 2015-10-28 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation. Antimicrob.Agents Chemother., 59, 2015
5E8L	Crystal structure of geranylgeranyl pyrophosphate synthase 11 from Arabidopsis thaliana Descriptor: Heterodimeric geranylgeranyl pyrophosphate synthase large subunit 1, chloroplastic Authors: Wang, C, Chen, Q, Fan, D, Li, J, Wang, G, Zhang, P. Deposit date: 2015-10-14 Release date: 2015-11-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.807 Å) Cite: Structural Analyses of Short-Chain Prenyltransferases Identify an Evolutionarily Conserved GFPPS Clade in Brassicaceae Plants. Mol Plant, 9, 2016

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