5CG6
Neutron crystal structure of human farnesyl pyrophosphate synthase in complex with risedronate and isopentenyl pyrophosphate
Summary for 5CG6
Entry DOI | 10.2210/pdb5cg6/pdb |
Related | 5cg5 |
Descriptor | Farnesyl pyrophosphate synthase, MAGNESIUM ION, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, ... (5 entities in total) |
Functional Keywords | prenyl transferase, bisphosphonate, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 41632.97 |
Authors | Yokoyama, T.,Mizuguchi, M.,Ostermann, A.,Kusaka, K.,Niimura, N.,Schrader, T.E.,Tanaka, I. (deposition date: 2015-07-09, release date: 2015-10-14, Last modification date: 2024-04-03) |
Primary citation | Yokoyama, T.,Mizuguchi, M.,Ostermann, A.,Kusaka, K.,Niimura, N.,Schrader, T.E.,Tanaka, I. Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase J.Med.Chem., 58:7549-7556, 2015 Cited by PubMed: 26314394DOI: 10.1021/acs.jmedchem.5b01147 PDB entries with the same primary citation |
Experimental method | NEUTRON DIFFRACTION (2.4 Å) X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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