5CG6
Neutron crystal structure of human farnesyl pyrophosphate synthase in complex with risedronate and isopentenyl pyrophosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Farnesyl pyrophosphate synthase | polymer | 355 | 41030.8 | 1 | UniProt (P14324) Pfam (PF00348) In PDB | Homo sapiens (Human) | FPS,(2E,6E)-farnesyl diphosphate synthase,Dimethylallyltranstransferase,Farnesyl diphosphate synthase,Geranyltranstransferase |
| 2 | A | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 3 | A | 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID | non-polymer | 283.1 | 1 | Chemie (RIS) | |||
| 4 | A | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE | non-polymer | 246.1 | 1 | Chemie (IPE) | |||
| 5 | water | water | 18.0 | 47 | Chemie (DOD) |
Sequence modifications
A: 8 - 353 (UniProt: P14324)
| PDB | External Database | Details |
|---|---|---|
| Met 7 | - | initiating methionine |
| Leu 354 | - | expression tag |
| Glu 355 | - | expression tag |
| His 356 | - | expression tag |
| His 357 | - | expression tag |
| His 358 | - | expression tag |
| His 359 | - | expression tag |
| His 360 | - | expression tag |
| His 361 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41030.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 602.1 | |
| All* | Total formula weight | 41633.0 |
