5CG5

Neutron crystal structure of human farnesyl pyrophosphate synthase in complex with risedronate

Summary for 5CG5

Entry DOI	10.2210/pdb5cg5/pdb
Related	5cg6
Descriptor	Farnesyl pyrophosphate synthase, MAGNESIUM ION, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, ... (4 entities in total)
Functional Keywords	prenyl transferase, bisphophonate, osteoprosis, inhibitor, transferase-transferase inhibotor complex, transferase/transferase inhibotor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	41386.88
Authors	Yokoyama, T.,Mizuguchi, M.,Ostermann, A.,Kusaka, K.,Niimura, N.,Schrader, T.E.,Tanaka, I. (deposition date: 2015-07-09, release date: 2015-10-14, Last modification date: 2024-04-03)
Primary citation	Yokoyama, T.,Mizuguchi, M.,Ostermann, A.,Kusaka, K.,Niimura, N.,Schrader, T.E.,Tanaka, I. Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase J.Med.Chem., 58:7549-7556, 2015 Cited by PubMed: 26314394 DOI: 10.1021/acs.jmedchem.5b01147 PDB entries with the same primary citation
Experimental method	NEUTRON DIFFRACTION (2.4 Å) X-RAY DIFFRACTION (1.402 Å)

Structure validation