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5CG5

Neutron crystal structure of human farnesyl pyrophosphate synthase in complex with risedronate

Functional Information from GO Data
ChainGOidnamespacecontents
A0008299biological_processisoprenoid biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue MG A 401
ChainResidue
AASP103
AASP107
ARIS400
AMG402
ADOD501
ADOD502
ADOD503

site_idAC2
Number of Residues6
Detailsbinding site for residue MG A 402
ChainResidue
ARIS400
AMG401
ADOD504
ADOD505
AASP103
AASP107

site_idAC3
Number of Residues5
Detailsbinding site for residue MG A 403
ChainResidue
AASP243
ARIS400
ADOD506
ADOD507
ADOD508

site_idAC4
Number of Residues22
Detailsbinding site for residue RIS A 400
ChainResidue
AASP103
AASP107
AARG112
AGLN171
ALYS200
ATHR201
AASP243
ALYS257
AMG401
AMG402
AMG403
ADOD501
ADOD503
ADOD504
ADOD505
ADOD506
ADOD507
ADOD508
ADOD509
ADOD510
ADOD523
ADOD529

Functional Information from PROSITE/UniProt
site_idPS00444
Number of Residues13
DetailsPOLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. MGefFQIqDDYlD
ChainResidueDetails
AMET235-ASP247

site_idPS00723
Number of Residues15
DetailsPOLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LVaDDim..DssltRRG
ChainResidueDetails
ALEU100-GLY114

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:16684881, ECO:0007744|PDB:1ZW5
ChainResidueDetails
ALYS57
AARG60
AGLN96
AASP103
AASP107
AARG113

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING:
ChainResidueDetails
AARG112
ALYS200
ATHR201
AGLN240
ALYS257

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ALYS266

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Important for determining product chain length => ECO:0000250
ChainResidueDetails
APHE98
APHE99

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS57

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS287

226707

PDB entries from 2024-10-30

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