5AHU

T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-1326

Summary for 5AHU

Entry DOI	10.2210/pdb5ahu/pdb
Descriptor	FARNESYL PYROPHOSPHATE SYNTHASE, PUTATIVE, FARNESYL PYROPHOSPHATE SYNTHASE, [2-(1-heptyl-1H-imidazol-3-ium-3-yl)ethane-1,1-diyl]bis(phosphonate), ... (5 entities in total)
Functional Keywords	transferase
Biological source	TRYPANOSOMA BRUCEI More
Total number of polymer chains	4
Total formula weight	82774.47
Authors	Yang, G.,Oldfield, E.,No, J.H. (deposition date: 2015-02-09, release date: 2015-10-28, Last modification date: 2024-01-10)
Primary citation	Yang, G.,Zhu, W.,Kim, K.,Byun, S.Y.,Choi, G.,Wang, K.,Cha, J.S.,Cho, H.,Oldfield, E.,No, J.H. Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation. Antimicrob.Agents Chemother., 59:7530-, 2015 Cited by PubMed: 26392508 DOI: 10.1128/AAC.01873-15 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.69 Å)

Structure validation