5DGM

Crystal structure of human FPPS in complex with monophosphonate compound 7

Summary for 5DGM

Entry DOI	10.2210/pdb5dgm/pdb
Descriptor	Farnesyl pyrophosphate synthase, {2-[(phosphonomethyl)carbamoyl]-1H-benzo[g]indol-1-yl}acetic acid, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	transferase, isoprene biosynthesis, cholesterol biosynthesis
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	40641.10
Authors	Rondeau, J.M.,Bourgier, E.,Lehmann, S. (deposition date: 2015-08-28, release date: 2016-07-13, Last modification date: 2016-07-20)
Primary citation	Jahnke, W.,Bold, G.,Marzinzik, A.L.,Ofner, S.,Pelle, X.,Cotesta, S.,Bourgier, E.,Lehmann, S.,Henry, C.,Hemmig, R.,Stauffer, F.,Hartwieg, J.C.,Green, J.R.,Rondeau, J.M. A General Strategy for Targeting Drugs to Bone. Angew.Chem.Int.Ed.Engl., 54:14575-14579, 2015 Cited by PubMed: 26457482 DOI: 10.1002/anie.201507064 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.86 Å)

Structure validation