5DJV

Crystal structure of human FPPS in complex with biaryl compound 8e

Summary for 5DJV

Entry DOI	10.2210/pdb5djv/pdb
Related	5DGN 5DIQ 5DJP 5DJR
Descriptor	Farnesyl pyrophosphate synthase, 8-(naphthalen-1-yl)-6-(1H-pyrrol-2-yl)quinoline-2-carboxylic acid (3 entities in total)
Functional Keywords	transferase, isoprene biosynthesis, cholesterol biosynthesis
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	40548.25
Authors	Rondeau, J.M.,Bourgier, E.,Lehmann, S. (deposition date: 2015-09-02, release date: 2015-10-07, Last modification date: 2015-11-04)
Primary citation	Marzinzik, A.L.,Amstutz, R.,Bold, G.,Bourgier, E.,Cotesta, S.,Glickman, J.F.,Gotte, M.,Henry, C.,Lehmann, S.,Hartwieg, J.C.,Ofner, S.,Pelle, X.,Roddy, T.P.,Rondeau, J.M.,Stauffer, F.,Stout, S.J.,Widmer, A.,Zimmermann, J.,Zoller, T.,Jahnke, W. Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10:1884-1891, 2015 Cited by PubMed: 26381451 DOI: 10.1002/cmdc.201500338 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation