5DIQ
Crystal structure of human FPPS in complex with salicylic acid derivative 3a
Summary for 5DIQ
Entry DOI | 10.2210/pdb5diq/pdb |
Related | 5DGN |
Descriptor | Farnesyl pyrophosphate synthase, GLYCEROL, 2-(naphthalen-1-ylmethoxy)benzoic acid, ... (6 entities in total) |
Functional Keywords | transferase, isoprene biosynthesis, cholesterol biosynthesis |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 40765.62 |
Authors | Rondeau, J.M.,Bourgier, E.,Lehmann, S. (deposition date: 2015-09-01, release date: 2015-09-30, Last modification date: 2024-05-08) |
Primary citation | Marzinzik, A.L.,Amstutz, R.,Bold, G.,Bourgier, E.,Cotesta, S.,Glickman, J.F.,Gotte, M.,Henry, C.,Lehmann, S.,Hartwieg, J.C.,Ofner, S.,Pelle, X.,Roddy, T.P.,Rondeau, J.M.,Stauffer, F.,Stout, S.J.,Widmer, A.,Zimmermann, J.,Zoller, T.,Jahnke, W. Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10:1884-1891, 2015 Cited by PubMed: 26381451DOI: 10.1002/cmdc.201500338 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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