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5DIQ

Crystal structure of human FPPS in complex with salicylic acid derivative 3a

Summary for 5DIQ
Entry DOI10.2210/pdb5diq/pdb
Related5DGN
DescriptorFarnesyl pyrophosphate synthase, GLYCEROL, 2-(naphthalen-1-ylmethoxy)benzoic acid, ... (6 entities in total)
Functional Keywordstransferase, isoprene biosynthesis, cholesterol biosynthesis
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P14324
Total number of polymer chains1
Total formula weight40765.62
Authors
Rondeau, J.M.,Bourgier, E.,Lehmann, S. (deposition date: 2015-09-01, release date: 2015-09-30, Last modification date: 2024-05-08)
Primary citationMarzinzik, A.L.,Amstutz, R.,Bold, G.,Bourgier, E.,Cotesta, S.,Glickman, J.F.,Gotte, M.,Henry, C.,Lehmann, S.,Hartwieg, J.C.,Ofner, S.,Pelle, X.,Roddy, T.P.,Rondeau, J.M.,Stauffer, F.,Stout, S.J.,Widmer, A.,Zimmermann, J.,Zoller, T.,Jahnke, W.
Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding.
Chemmedchem, 10:1884-1891, 2015
Cited by
PubMed: 26381451
DOI: 10.1002/cmdc.201500338
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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