5DIQ

Crystal structure of human FPPS in complex with salicylic acid derivative 3a

Summary for 5DIQ

Entry DOI	10.2210/pdb5diq/pdb
Related	5DGN
Descriptor	Farnesyl pyrophosphate synthase, GLYCEROL, 2-(naphthalen-1-ylmethoxy)benzoic acid, ... (6 entities in total)
Functional Keywords	transferase, isoprene biosynthesis, cholesterol biosynthesis
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	40765.62
Authors	Rondeau, J.M.,Bourgier, E.,Lehmann, S. (deposition date: 2015-09-01, release date: 2015-09-30, Last modification date: 2024-05-08)
Primary citation	Marzinzik, A.L.,Amstutz, R.,Bold, G.,Bourgier, E.,Cotesta, S.,Glickman, J.F.,Gotte, M.,Henry, C.,Lehmann, S.,Hartwieg, J.C.,Ofner, S.,Pelle, X.,Roddy, T.P.,Rondeau, J.M.,Stauffer, F.,Stout, S.J.,Widmer, A.,Zimmermann, J.,Zoller, T.,Jahnke, W. Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10:1884-1891, 2015 Cited by PubMed: 26381451 DOI: 10.1002/cmdc.201500338 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation