5DGS

Crystal structure of human FPPS in complex with the monophosphonate compound 15

Summary for 5DGS

• Entry DOI: 10.2210/pdb5dgs/pdb
• Related: 5DGM 5DGN
• Descriptor: Farnesyl pyrophosphate synthase, {(E)-2-[6-(acetylamino)-8-(naphthalen-1-yl)quinolin-2-yl]ethenyl}phosphonic acid (3 entities in total)
• Functional Keywords: transferase, isoprene biosynthesis, cholesterol biosynthesis
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P14324
• Total number of polymer chains: 1
• Total formula weight: 40602.24

Authors

Rondeau, J.M.,Bourgier, E.,Lehmann, S. (deposition date: 2015-08-28, release date: 2016-07-13, Last modification date: 2017-11-29)

• Primary citation: Jahnke, W.,Bold, G.,Marzinzik, A.L.,Ofner, S.,Pelle, X.,Cotesta, S.,Bourgier, E.,Lehmann, S.,Henry, C.,Hemmig, R.,Stauffer, F.,Hartwieg, J.C.,Green, J.R.,Rondeau, J.M.; A General Strategy for Targeting Drugs to Bone.; Angew.Chem.Int.Ed.Engl., 54:14575-14579, 2015; PubMed: 26457482; DOI: 10.1002/anie.201507064

Experimental method

X-RAY DIFFRACTION (2.62 Å)