5DGS
Crystal structure of human FPPS in complex with the monophosphonate compound 15
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (F) | Farnesyl pyrophosphate synthase | polymer | 350 | 40183.9 | 1 | UniProt (P14324) Pfam (PF00348) | Homo sapiens (Human) | FPS,(2E,6E)-farnesyl diphosphate synthase,Dimethylallyltranstransferase,Farnesyl diphosphate synthase,Geranyltranstransferase |
| 2 | B (F) | {(E)-2-[6-(acetylamino)-8-(naphthalen-1-yl)quinolin-2-yl]ethenyl}phosphonic acid | non-polymer | 418.4 | 1 | Chemie (5A7) | |||
| 3 | C (F) | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
F: 6 - 353 (UniProt: P14324)
| PDB | External Database | Details |
|---|---|---|
| Gly 4 | - | expression tag |
| Pro 5 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40183.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 418.4 | |
| All* | Total formula weight | 40602.2 |
