5BVP

The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta

Summary for 5BVP

Entry DOI	10.2210/pdb5bvp/pdb
Descriptor	canakinumab Fab heavy-chain, Interleukin-1 beta, Canakinumab Fab light-chain, ... (5 entities in total)
Functional Keywords	immunoglobulin, fab, cytokine, beta trefoil, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	65027.70
Authors	Rondeau, J.M. (deposition date: 2015-06-05, release date: 2015-09-02, Last modification date: 2024-01-10)
Primary citation	Rondeau, J.M.,Ramage, P.,Zurini, M.,Gram, H. The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1 beta. Mabs, 7:1151-1160, 2015 Cited by PubMed: 26284424 DOI: 10.1080/19420862.2015.1081323 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation