5BVP
The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | canakinumab Fab heavy-chain | polymer | 225 | 24179.1 | 1 | Homo sapiens (Human) | ILARIS Fab | |
| 2 | B (I) | Interleukin-1 beta | polymer | 153 | 17395.8 | 1 | UniProt (P01584) Pfam (PF00340) | Homo sapiens (Human) | IL-1 beta,Catabolin |
| 3 | C (L) | Canakinumab Fab light-chain | polymer | 214 | 23381.9 | 1 | Homo sapiens (Human) | ILARIS Fab | |
| 4 | D, E (I, L) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | F, G, H (H, I, L) | water | water | 18.0 | 254 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 64956.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 70.9 | |
| All* | Total formula weight | 65027.7 |
