8CE7
 
 | | Type1 alpha-synuclein filament assembled in vitro by wild-type and mutant (7 residues insertion) protein | | Descriptor: | Alpha-synuclein | | Authors: | Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Peak-Chew, S.Y, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. | | Deposit date: | 2023-02-01 | | Release date: | 2023-03-01 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy.
Acta Neuropathol, 145, 2023
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8CEB
 | | Type2 alpha-synuclein filament assembled in vitro by wild-type and mutant (7 residues insertion) protein | | Descriptor: | Alpha-synuclein | | Authors: | Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Sew, P.C, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. | | Deposit date: | 2023-02-01 | | Release date: | 2023-03-08 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy.
Acta Neuropathol, 145, 2023
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6ZV6
 | | Human RIO1(kd)-StHA late pre-40S particle, structural state B (post 18S rRNA cleavage) | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Plassart, L, Shayan, R, Plisson-Chastang, C. | | Deposit date: | 2020-07-24 | | Release date: | 2021-05-12 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | The final step of 40S ribosomal subunit maturation is controlled by a dual key lock.
Elife, 10, 2021
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4UG0
 | | STRUCTURE OF THE HUMAN 80S RIBOSOME | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S RIBOSOMAL PROTEIN, ... | | Authors: | Khatter, H, Myasnikov, A.G, Natchiar, S.K, Klaholz, B.P. | | Deposit date: | 2015-03-20 | | Release date: | 2015-06-10 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structure of the human 80S ribosome
NATURE, 520, 2015
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5A2Q
 | | Structure of the HCV IRES bound to the human ribosome | | Descriptor: | 18S RRNA, HCV IRES, MAGNESIUM ION, ... | | Authors: | Quade, N, Leiundgut, M, Boehringer, D, Heuvel, J.v.d, Ban, N. | | Deposit date: | 2015-05-21 | | Release date: | 2015-07-15 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Cryo-Em Structure of Hepatitis C Virus Ires Bound to the Human Ribosome at 3.9 Angstrom Resolution
Nat.Commun., 6, 2015
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8PPL
 | | MERS-CoV Nsp1 bound to the human 43S pre-initiation complex | | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Schubert, K, Karousis, E.D, Ban, I, Lapointe, C.P, Leibundgut, M, Baeumlin, E, Kummerant, E, Scaiola, A, Schoenhut, T, Ziegelmueller, J, Puglisi, J.D, Muehlemann, O, Ban, N. | | Deposit date: | 2023-07-07 | | Release date: | 2023-10-18 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.65 Å) | | Cite: | Universal features of Nsp1-mediated translational shutdown by coronaviruses.
Mol.Cell, 83, 2023
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7ANE
 | | Leishmania Major mitochondrial ribosome | | Descriptor: | 30S Ribosomal protein S17-like protein, 50S ribosomal protein L13-like protein, AKAP7_NLS domain-containing protein, ... | | Authors: | Soufari, H, Waltz, F, Parrot, C, Bochler, A, Hashem, Y. | | Deposit date: | 2020-10-11 | | Release date: | 2021-06-23 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesis.
Proc.Natl.Acad.Sci.USA, 117, 2020
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8PPK
 | | Bat-Hp-CoV Nsp1 and eIF1 bound to the human 40S small ribosomal subunit | | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Schubert, K, Karousis, E.D, Ban, I, Lapointe, C.P, Leibundgut, M, Baeumlin, E, Kummerant, E, Scaiola, A, Schoenhut, T, Ziegelmueller, J, Puglisi, J.D, Muehlemann, O, Ban, N. | | Deposit date: | 2023-07-07 | | Release date: | 2023-10-18 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Universal features of Nsp1-mediated translational shutdown by coronaviruses.
Mol.Cell, 83, 2023
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6QZP
 | | High-resolution cryo-EM structure of the human 80S ribosome | | Descriptor: | (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 18S rRNA (1740-MER), 28S rRNA (3773-MER), ... | | Authors: | Natchiar, S.K, Myasnikov, A.G, Kratzat, H, Hazemann, I, Klaholz, B.P. | | Deposit date: | 2019-03-12 | | Release date: | 2019-04-24 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Visualization of chemical modifications in the human 80S ribosome structure.
Nature, 551, 2017
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7QP6
 | | Structure of the human 48S initiation complex in open state (h48S AUG open) | | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Yi, S.-H, Petrychenko, V, Schliep, J.E, Goyal, A, Linden, A, Chari, A, Urlaub, H, Stark, H, Rodnina, M.V, Adio, S, Fischer, N. | | Deposit date: | 2022-01-03 | | Release date: | 2022-05-11 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Conformational rearrangements upon start codon recognition in human 48S translation initiation complex.
Nucleic Acids Res., 50, 2022
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7OUF
 | | Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor XZ450 | | Descriptor: | 4-azanyl-~{N}-[[2,4-bis(fluoranyl)phenyl]methyl]-6-[3-(dimethylamino)-3-oxidanylidene-propyl]-1-oxidanyl-2-oxidanylidene-1,8-naphthyridine-3-carboxamide, DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*AP*GP*AP*AP*GP*CP*GP*CP*CP*AP*AP*AP*CP*AP*CP*A)-3'), ... | | Authors: | Barski, M.S, Ballandras-Colas, A, Cronin, N.B, Pye, V.E, Cherepanov, P, Maertens, G.N. | | Deposit date: | 2021-06-11 | | Release date: | 2021-08-18 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures.
Nat Commun, 12, 2021
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7QP7
 | | Structure of the human 48S initiation complex in closed state (h48S AUG closed) | | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Yi, S.-H, Petrychenko, V, Schliep, J.E, Goyal, A, Linden, A, Chari, A, Urlaub, H, Stark, H, Rodnina, M.V, Adio, S, Fischer, N. | | Deposit date: | 2022-01-03 | | Release date: | 2022-05-11 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Conformational rearrangements upon start codon recognition in human 48S translation initiation complex.
Nucleic Acids Res., 50, 2022
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6ZOL
 | | SARS-CoV-2-Nsp1-40S complex, focused on head | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S12, ... | | Authors: | Schubert, K, Karousis, E.D, Jomaa, A, Scaiola, A, Echeverria, B, Gurzeler, L.-A, Leibundgut, M.L, Thiel, V, Muehlemann, O, Ban, N. | | Deposit date: | 2020-07-07 | | Release date: | 2020-07-22 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation.
Nat.Struct.Mol.Biol., 27, 2020
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7TQL
 | | CryoEM structure of the human 40S small ribosomal subunit in complex with translation initiation factors eIF1A and eIF5B. | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Lapointe, C.P, Grosely, R, Sokabe, M, Alvarado, C, Wang, J, Montabana, E, Villa, N, Shin, B, Dever, T, Fraser, C, Fernandez, I.S, Puglisi, J.D. | | Deposit date: | 2022-01-26 | | Release date: | 2022-04-27 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining.
Nature, 607, 2022
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7QVP
 | | Human collided disome (di-ribosome) stalled on XBP1 mRNA | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | Authors: | Denk, T.G, Tesina, P, Beckmann, R. | | Deposit date: | 2022-01-22 | | Release date: | 2022-10-12 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.
Nat Commun, 13, 2022
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5LKS
 | | Structure-function insights reveal the human ribosome as a cancer target for antibiotics | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | | Authors: | Myasnikov, A.G, Natchiar, S.K, Nebout, M, Hazemann, I, Imbert, V, Khatter, H, Peyron, J.-F, Klaholz, B.P. | | Deposit date: | 2016-07-23 | | Release date: | 2017-04-26 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
Nat Commun, 7, 2016
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1F5T
 | | DIPHTHERIA TOX REPRESSOR (C102D MUTANT) COMPLEXED WITH NICKEL AND DTXR CONSENSUS BINDING SEQUENCE | | Descriptor: | 43MER DNA CONTAINING DXTR CONSENSUS BINDING SEQUENCE, DIPHTHERIA TOXIN REPRESSOR, NICKEL (II) ION | | Authors: | Chen, S, White, A, Love, J, Murphy, J.R, Ringe, D. | | Deposit date: | 2000-06-15 | | Release date: | 2000-09-25 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Methyl groups of thymine bases are important for nucleic acid recognition by DtxR.
Biochemistry, 39, 2000
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5SVA
 | | Mediator-RNA Polymerase II Pre-Initiation Complex | | Descriptor: | 108bp HIS4 Promoter Non-template Strand (-92/+16), 108bp HIS4 Promoter Template Strand (+16/-92), DNA repair helicase RAD25, ... | | Authors: | Robinson, P.J, Bushnell, D.A, Kornberg, R.D. | | Deposit date: | 2016-08-05 | | Release date: | 2016-09-28 | | Last modified: | 2019-11-27 | | Method: | ELECTRON MICROSCOPY (15.3 Å) | | Cite: | Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex.
Cell, 166, 2016
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6FEC
 | | Human cap-dependent 48S pre-initiation complex | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Schaffitzel, C, Schaffitzel, C. | | Deposit date: | 2017-12-31 | | Release date: | 2018-03-14 | | Last modified: | 2018-10-03 | | Method: | ELECTRON MICROSCOPY (6.3 Å) | | Cite: | Structure of a human cap-dependent 48S translation pre-initiation complex.
Nucleic Acids Res., 46, 2018
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8ABY
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8AC0
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8ACP
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7O4J
 | | Yeast RNA polymerase II transcription pre-initiation complex (consensus) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase II subunit RPB1, ... | | Authors: | Schilbach, S, Aibara, S, Dienemann, C, Grabbe, F, Cramer, P. | | Deposit date: | 2021-04-06 | | Release date: | 2021-06-16 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure of RNA polymerase II pre-initiation complex at 2.9 angstrom defines initial DNA opening.
Cell, 184, 2021
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7O4I
 | | Yeast RNA polymerase II transcription pre-initiation complex with initial transcription bubble | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase II subunit RPB1, ... | | Authors: | Schilbach, S, Aibara, S, Dienemann, C, Grabbe, F, Cramer, P. | | Deposit date: | 2021-04-06 | | Release date: | 2021-06-16 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of RNA polymerase II pre-initiation complex at 2.9 angstrom defines initial DNA opening.
Cell, 184, 2021
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7O75
 | | Yeast RNA polymerase II transcription pre-initiation complex with open promoter DNA | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase II subunit RPB1, ... | | Authors: | Schilbach, S, Aibara, S, Dienemann, C, Grabbe, F, Cramer, P. | | Deposit date: | 2021-04-13 | | Release date: | 2021-06-16 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of RNA polymerase II pre-initiation complex at 2.9 angstrom defines initial DNA opening.
Cell, 184, 2021
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