5LKS

Structure-function insights reveal the human ribosome as a cancer target for antibiotics

This is a large structure.

Summary for 5LKS

EMDB information4070
Descriptor28S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ... (84 entities in total)
Functional Keywordscryoem, human ribosome, 80s, cycloheximide, ribosome
Biological sourceHomo sapiens (Human)
Total number of polymer chains80
Total molecular weight3818879.56
Authors
Myasnikov, A.G.,Natchiar, S.K.,Nebout, M.,Hazemann, I.,Imbert, V.,Khatter, H.,Peyron, J.-F.,Klaholz, B.P. (deposition date: 2016-07-23, release date: 2017-04-26, Last modification date: 2019-12-11)
Primary citation
Myasnikov, A.G.,Kundhavai Natchiar, S.,Nebout, M.,Hazemann, I.,Imbert, V.,Khatter, H.,Peyron, J.F.,Klaholz, B.P.
Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
Nat Commun, 7:12856-12856, 2016
PubMed: 27665925 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms12856
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone55 2.9% 0.1% 0.33MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation reportDownload
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PDB entries from 2020-08-05