8CE7
Type1 alpha-synuclein filament assembled in vitro by wild-type and mutant (7 residues insertion) protein
Summary for 8CE7
Entry DOI | 10.2210/pdb8ce7/pdb |
EMDB information | 16600 |
Descriptor | Alpha-synuclein (1 entity in total) |
Functional Keywords | alpha-synuclein, amyloid, fibril, insertion, mutation, in vitro, recombinant, synucleinopathy, protein fibril |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 28952.22 |
Authors | Yang, Y.,Garringer, J.H.,Shi, Y.,Lovestam, S.,Peak-Chew, S.Y.,Zhang, X.J.,Kotecha, A.,Bacioglu, M.,Koto, A.,Takao, M.,Spillantini, G.M.,Ghetti, B.,Vidal, R.,Murzin, G.A.,Scheres, H.W.S.,Goedert, M. (deposition date: 2023-02-01, release date: 2023-03-01, Last modification date: 2024-07-24) |
Primary citation | Yang, Y.,Garringer, H.J.,Shi, Y.,Lovestam, S.,Peak-Chew, S.,Zhang, X.,Kotecha, A.,Bacioglu, M.,Koto, A.,Takao, M.,Spillantini, M.G.,Ghetti, B.,Vidal, R.,Murzin, A.G.,Scheres, S.H.W.,Goedert, M. New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy. Acta Neuropathol, 145:561-572, 2023 Cited by PubMed: 36847833DOI: 10.1007/s00401-023-02550-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.7 Å) |
Structure validation
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