7OUF
Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor XZ450
Summary for 7OUF
Entry DOI | 10.2210/pdb7ouf/pdb |
EMDB information | 13075 |
Descriptor | Integrase, Isoform 3 of PC4 and SFRS1-interacting protein,Isoform Gamma-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3'), ... (8 entities in total) |
Functional Keywords | stlv-1 intasome, integrase strand-transfer inhibitor, htlv, raltegravir, viral protein |
Biological source | Simian T-lymphotropic virus 1 More |
Total number of polymer chains | 10 |
Total formula weight | 333444.15 |
Authors | Barski, M.S.,Ballandras-Colas, A.,Cronin, N.B.,Pye, V.E.,Cherepanov, P.,Maertens, G.N. (deposition date: 2021-06-11, release date: 2021-08-18, Last modification date: 2024-07-17) |
Primary citation | Barski, M.S.,Vanzo, T.,Zhao, X.Z.,Smith, S.J.,Ballandras-Colas, A.,Cronin, N.B.,Pye, V.E.,Hughes, S.H.,Burke Jr., T.R.,Cherepanov, P.,Maertens, G.N. Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures. Nat Commun, 12:4996-4996, 2021 Cited by PubMed: 34404793DOI: 10.1038/s41467-021-25284-1 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3 Å) |
Structure validation
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