7OUF

Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor XZ450

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	D, E, A, B	Integrase	polymer	301	33943.5	4	UniProt (Q4QY51) Pfam (PF02022) Pfam (PF00665) Pfam (PF00552) In PDB	Simian T-lymphotropic virus 1
2	F, C	Isoform 3 of PC4 and SFRS1-interacting protein,Isoform Gamma-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	polymer	697	80394.7	2	UniProt (O75475) UniProt (Q13362) Pfam (PF00855) Pfam (PF01603) In PDB	Homo sapiens (Human)	CLL-associated antigen KW-7,Dense fine speckles 70 kDa protein,DFS 70,Lens epithelium-derived growth factor,Transcriptional coactivator p75/p52,PP2A B subunit isoform B'-gamma,PP2A B subunit isoform B56-gamma,PP2A B subunit isoform PR61-gamma,PP2A B subunit isoform R5-gamma,Renal carcinoma antigen NY-REN-29
3	I, K	DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3')	polymer	30	9221.9	2		Simian T-lymphotropic virus 1
4	J, H	DNA (5'-D(*GP*AP*GP*AP*GP*AP*AP*GP*CP*GP*CP*CP*AP*AP*AP*CP*AP*CP*A)-3')	polymer	28	8593.6	2		Simian T-lymphotropic virus 1
5	D, E, A, B	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
6	E, B	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
7	E, B	4-azanyl-~{N}-[[2,4-bis(fluoranyl)phenyl]methyl]-6-[3-(dimethylamino)-3-oxidanylidene-propyl]-1-oxidanyl-2-oxidanylidene-1,8-naphthyridine-3-carboxamide	non-polymer		445.4	2	Chemie (1L0)
8		water	water		18.0	12	Chemie (HOH)

Sequence modifications

D, E, A, B: -2 - 297 (UniProt: Q4QY51)

PDB	External Database	Details
Gly -3	-	expression tag
Glu -1	Val 598	expression tag
Phe 0	Leu 599	expression tag
Glu 219	Ala 818	engineered mutation

F, C: -315 - 9 (UniProt: O75475)

PDB	External Database	Details
Ser -316	-	expression tag
Phe 10	-	linker

F, C: 11 - 380 (UniProt: Q13362)

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	332194.5
Non-Polymers*	Number of molecules	10
	Total formula weight	1249.7
All*	Total formula weight	333444.1

*Water molecules are not included.