8CEB

Type2 alpha-synuclein filament assembled in vitro by wild-type and mutant (7 residues insertion) protein

Summary for 8CEB

Entry DOI	10.2210/pdb8ceb/pdb
EMDB information	16603
Descriptor	Alpha-synuclein (1 entity in total)
Functional Keywords	alpha-synuclein, amyloid, fibril, insertion, mutation, in vitro, recombinant, synucleinopathy, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	28952.22
Authors	Yang, Y.,Garringer, J.H.,Shi, Y.,Lovestam, S.,Sew, P.C.,Zhang, X.J.,Kotecha, A.,Bacioglu, M.,Koto, A.,Takao, M.,Spillantini, G.M.,Ghetti, B.,Vidal, R.,Murzin, G.A.,Scheres, H.W.S.,Goedert, M. (deposition date: 2023-02-01, release date: 2023-03-08, Last modification date: 2023-05-03)
Primary citation	Yang, Y.,Garringer, H.J.,Shi, Y.,Lovestam, S.,Peak-Chew, S.,Zhang, X.,Kotecha, A.,Bacioglu, M.,Koto, A.,Takao, M.,Spillantini, M.G.,Ghetti, B.,Vidal, R.,Murzin, A.G.,Scheres, S.H.W.,Goedert, M. New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy. Acta Neuropathol, 145:561-572, 2023 Cited by PubMed: 36847833 DOI: 10.1007/s00401-023-02550-8 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.7 Å)

Structure validation