8CEB

Type2 alpha-synuclein filament assembled in vitro by wild-type and mutant (7 residues insertion) protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000149	molecular_function	SNARE binding
A	0000287	molecular_function	magnesium ion binding
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0001774	biological_process	microglial cell activation
A	0001921	biological_process	positive regulation of receptor recycling
A	0001956	biological_process	positive regulation of neurotransmitter secretion
A	0001963	biological_process	synaptic transmission, dopaminergic
A	0003779	molecular_function	actin binding
A	0004857	molecular_function	enzyme inhibitor activity
A	0004860	molecular_function	protein kinase inhibitor activity
A	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
A	0005504	molecular_function	fatty acid binding
A	0005507	molecular_function	copper ion binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005640	cellular_component	nuclear outer membrane
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005743	cellular_component	mitochondrial inner membrane
A	0005759	cellular_component	mitochondrial matrix
A	0005764	cellular_component	lysosome
A	0005829	cellular_component	cytosol
A	0005840	cellular_component	ribosome
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0005938	cellular_component	cell cortex
A	0006631	biological_process	fatty acid metabolic process
A	0006638	biological_process	neutral lipid metabolic process
A	0006644	biological_process	phospholipid metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0007006	biological_process	mitochondrial membrane organization
A	0007268	biological_process	chemical synaptic transmission
A	0007269	biological_process	neurotransmitter secretion
A	0008017	molecular_function	microtubule binding
A	0008021	cellular_component	synaptic vesicle
A	0008047	molecular_function	enzyme activator activity
A	0008198	molecular_function	ferrous iron binding
A	0008270	molecular_function	zinc ion binding
A	0008289	molecular_function	lipid binding
A	0008344	biological_process	adult locomotory behavior
A	0009410	biological_process	response to xenobiotic stimulus
A	0010040	biological_process	response to iron(II) ion
A	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
A	0014048	biological_process	regulation of glutamate secretion
A	0014059	biological_process	regulation of dopamine secretion
A	0015629	cellular_component	actin cytoskeleton
A	0015631	molecular_function	tubulin binding
A	0016020	cellular_component	membrane
A	0016079	biological_process	synaptic vesicle exocytosis
A	0016082	biological_process	synaptic vesicle priming
A	0016234	cellular_component	inclusion body
A	0016491	molecular_function	oxidoreductase activity
A	0019894	molecular_function	kinesin binding
A	0019899	molecular_function	enzyme binding
A	0019904	molecular_function	protein domain specific binding
A	0030424	cellular_component	axon
A	0030426	cellular_component	growth cone
A	0030544	molecular_function	Hsp70 protein binding
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0030672	cellular_component	synaptic vesicle membrane
A	0031092	cellular_component	platelet alpha granule membrane
A	0031115	biological_process	negative regulation of microtubule polymerization
A	0031623	biological_process	receptor internalization
A	0031648	biological_process	protein destabilization
A	0032026	biological_process	response to magnesium ion
A	0032496	biological_process	response to lipopolysaccharide
A	0032991	cellular_component	protein-containing complex
A	0034341	biological_process	response to type II interferon
A	0034599	biological_process	cellular response to oxidative stress
A	0035493	biological_process	SNARE complex assembly
A	0035543	biological_process	positive regulation of SNARE complex assembly
A	0040012	biological_process	regulation of locomotion
A	0042220	biological_process	response to cocaine
A	0042393	molecular_function	histone binding
A	0042416	biological_process	dopamine biosynthetic process
A	0042417	biological_process	dopamine metabolic process
A	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
A	0042802	molecular_function	identical protein binding
A	0043014	molecular_function	alpha-tubulin binding
A	0043025	cellular_component	neuronal cell body
A	0043030	biological_process	regulation of macrophage activation
A	0043065	biological_process	positive regulation of apoptotic process
A	0043066	biological_process	negative regulation of apoptotic process
A	0043195	cellular_component	terminal bouton
A	0043274	molecular_function	phospholipase binding
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0043679	cellular_component	axon terminus
A	0044344	biological_process	cellular response to fibroblast growth factor stimulus
A	0045202	cellular_component	synapse
A	0045807	biological_process	positive regulation of endocytosis
A	0045920	biological_process	negative regulation of exocytosis
A	0045921	biological_process	positive regulation of exocytosis
A	0045963	biological_process	negative regulation of dopamine metabolic process
A	0046872	molecular_function	metal ion binding
A	0046928	biological_process	regulation of neurotransmitter secretion
A	0048148	biological_process	behavioral response to cocaine
A	0048156	molecular_function	tau protein binding
A	0048168	biological_process	regulation of neuronal synaptic plasticity
A	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0048487	molecular_function	beta-tubulin binding
A	0048488	biological_process	synaptic vesicle endocytosis
A	0048489	biological_process	synaptic vesicle transport
A	0050729	biological_process	positive regulation of inflammatory response
A	0050806	biological_process	positive regulation of synaptic transmission
A	0050808	biological_process	synapse organization
A	0050812	biological_process	regulation of acyl-CoA biosynthetic process
A	0051219	molecular_function	phosphoprotein binding
A	0051259	biological_process	protein complex oligomerization
A	0051262	biological_process	protein tetramerization
A	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
A	0051402	biological_process	neuron apoptotic process
A	0051583	biological_process	dopamine uptake involved in synaptic transmission
A	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
A	0051612	biological_process	negative regulation of serotonin uptake
A	0051621	biological_process	regulation of norepinephrine uptake
A	0051622	biological_process	negative regulation of norepinephrine uptake
A	0055074	biological_process	calcium ion homeostasis
A	0060079	biological_process	excitatory postsynaptic potential
A	0060291	biological_process	long-term synaptic potentiation
A	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
A	0060961	molecular_function	phospholipase D inhibitor activity
A	0061024	biological_process	membrane organization
A	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
A	0070507	biological_process	regulation of microtubule cytoskeleton organization
A	0070555	biological_process	response to interleukin-1
A	0070840	molecular_function	dynein complex binding
A	0071280	biological_process	cellular response to copper ion
A	0071872	biological_process	cellular response to epinephrine stimulus
A	0097413	cellular_component	Lewy body
A	0097435	biological_process	supramolecular fiber organization
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	0099512	cellular_component	supramolecular fiber
A	0140311	molecular_function	protein sequestering activity
A	0141108	molecular_function	transporter regulator activity
A	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
A	1903136	molecular_function	cuprous ion binding
A	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
A	1903421	biological_process	regulation of synaptic vesicle recycling
A	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
A	1904307	biological_process	response to desipramine
A	1904377	biological_process	positive regulation of protein localization to cell periphery
A	1904715	biological_process	negative regulation of chaperone-mediated autophagy
A	1905606	biological_process	regulation of presynapse assembly
A	1990000	biological_process	amyloid fibril formation
A	2000377	biological_process	regulation of reactive oxygen species metabolic process
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000149	molecular_function	SNARE binding
C	0000287	molecular_function	magnesium ion binding
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0001774	biological_process	microglial cell activation
C	0001921	biological_process	positive regulation of receptor recycling
C	0001956	biological_process	positive regulation of neurotransmitter secretion
C	0001963	biological_process	synaptic transmission, dopaminergic
C	0003779	molecular_function	actin binding
C	0004857	molecular_function	enzyme inhibitor activity
C	0004860	molecular_function	protein kinase inhibitor activity
C	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
C	0005504	molecular_function	fatty acid binding
C	0005507	molecular_function	copper ion binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005543	molecular_function	phospholipid binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005640	cellular_component	nuclear outer membrane
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005743	cellular_component	mitochondrial inner membrane
C	0005759	cellular_component	mitochondrial matrix
C	0005764	cellular_component	lysosome
C	0005829	cellular_component	cytosol
C	0005840	cellular_component	ribosome
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0005938	cellular_component	cell cortex
C	0006631	biological_process	fatty acid metabolic process
C	0006638	biological_process	neutral lipid metabolic process
C	0006644	biological_process	phospholipid metabolic process
C	0006749	biological_process	glutathione metabolic process
C	0007006	biological_process	mitochondrial membrane organization
C	0007268	biological_process	chemical synaptic transmission
C	0007269	biological_process	neurotransmitter secretion
C	0008017	molecular_function	microtubule binding
C	0008021	cellular_component	synaptic vesicle
C	0008047	molecular_function	enzyme activator activity
C	0008198	molecular_function	ferrous iron binding
C	0008270	molecular_function	zinc ion binding
C	0008289	molecular_function	lipid binding
C	0008344	biological_process	adult locomotory behavior
C	0009410	biological_process	response to xenobiotic stimulus
C	0010040	biological_process	response to iron(II) ion
C	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
C	0014048	biological_process	regulation of glutamate secretion
C	0014059	biological_process	regulation of dopamine secretion
C	0015629	cellular_component	actin cytoskeleton
C	0015631	molecular_function	tubulin binding
C	0016020	cellular_component	membrane
C	0016079	biological_process	synaptic vesicle exocytosis
C	0016082	biological_process	synaptic vesicle priming
C	0016234	cellular_component	inclusion body
C	0016491	molecular_function	oxidoreductase activity
C	0019894	molecular_function	kinesin binding
C	0019899	molecular_function	enzyme binding
C	0019904	molecular_function	protein domain specific binding
C	0030424	cellular_component	axon
C	0030426	cellular_component	growth cone
C	0030544	molecular_function	Hsp70 protein binding
C	0030659	cellular_component	cytoplasmic vesicle membrane
C	0030672	cellular_component	synaptic vesicle membrane
C	0031092	cellular_component	platelet alpha granule membrane
C	0031115	biological_process	negative regulation of microtubule polymerization
C	0031623	biological_process	receptor internalization
C	0031648	biological_process	protein destabilization
C	0032026	biological_process	response to magnesium ion
C	0032496	biological_process	response to lipopolysaccharide
C	0032991	cellular_component	protein-containing complex
C	0034341	biological_process	response to type II interferon
C	0034599	biological_process	cellular response to oxidative stress
C	0035493	biological_process	SNARE complex assembly
C	0035543	biological_process	positive regulation of SNARE complex assembly
C	0040012	biological_process	regulation of locomotion
C	0042220	biological_process	response to cocaine
C	0042393	molecular_function	histone binding
C	0042416	biological_process	dopamine biosynthetic process
C	0042417	biological_process	dopamine metabolic process
C	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
C	0042802	molecular_function	identical protein binding
C	0043014	molecular_function	alpha-tubulin binding
C	0043025	cellular_component	neuronal cell body
C	0043030	biological_process	regulation of macrophage activation
C	0043065	biological_process	positive regulation of apoptotic process
C	0043066	biological_process	negative regulation of apoptotic process
C	0043195	cellular_component	terminal bouton
C	0043274	molecular_function	phospholipase binding
C	0043524	biological_process	negative regulation of neuron apoptotic process
C	0043679	cellular_component	axon terminus
C	0044344	biological_process	cellular response to fibroblast growth factor stimulus
C	0045202	cellular_component	synapse
C	0045807	biological_process	positive regulation of endocytosis
C	0045920	biological_process	negative regulation of exocytosis
C	0045921	biological_process	positive regulation of exocytosis
C	0045963	biological_process	negative regulation of dopamine metabolic process
C	0046872	molecular_function	metal ion binding
C	0046928	biological_process	regulation of neurotransmitter secretion
C	0048148	biological_process	behavioral response to cocaine
C	0048156	molecular_function	tau protein binding
C	0048168	biological_process	regulation of neuronal synaptic plasticity
C	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0048487	molecular_function	beta-tubulin binding
C	0048488	biological_process	synaptic vesicle endocytosis
C	0048489	biological_process	synaptic vesicle transport
C	0050729	biological_process	positive regulation of inflammatory response
C	0050806	biological_process	positive regulation of synaptic transmission
C	0050808	biological_process	synapse organization
C	0050812	biological_process	regulation of acyl-CoA biosynthetic process
C	0051219	molecular_function	phosphoprotein binding
C	0051259	biological_process	protein complex oligomerization
C	0051262	biological_process	protein tetramerization
C	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
C	0051402	biological_process	neuron apoptotic process
C	0051583	biological_process	dopamine uptake involved in synaptic transmission
C	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
C	0051612	biological_process	negative regulation of serotonin uptake
C	0051621	biological_process	regulation of norepinephrine uptake
C	0051622	biological_process	negative regulation of norepinephrine uptake
C	0055074	biological_process	calcium ion homeostasis
C	0060079	biological_process	excitatory postsynaptic potential
C	0060291	biological_process	long-term synaptic potentiation
C	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
C	0060961	molecular_function	phospholipase D inhibitor activity
C	0061024	biological_process	membrane organization
C	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
C	0070507	biological_process	regulation of microtubule cytoskeleton organization
C	0070555	biological_process	response to interleukin-1
C	0070840	molecular_function	dynein complex binding
C	0071280	biological_process	cellular response to copper ion
C	0071872	biological_process	cellular response to epinephrine stimulus
C	0097413	cellular_component	Lewy body
C	0097435	biological_process	supramolecular fiber organization
C	0098793	cellular_component	presynapse
C	0098794	cellular_component	postsynapse
C	0099512	cellular_component	supramolecular fiber
C	0140311	molecular_function	protein sequestering activity
C	0141108	molecular_function	transporter regulator activity
C	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
C	1903136	molecular_function	cuprous ion binding
C	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
C	1903421	biological_process	regulation of synaptic vesicle recycling
C	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
C	1904307	biological_process	response to desipramine
C	1904377	biological_process	positive regulation of protein localization to cell periphery
C	1904715	biological_process	negative regulation of chaperone-mediated autophagy
C	1905606	biological_process	regulation of presynapse assembly
C	1990000	biological_process	amyloid fibril formation
C	2000377	biological_process	regulation of reactive oxygen species metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Repeat: {"description":"3; approximate"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	20
Details	Repeat: {"description":"4"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"10617630","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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