8PPK

Bat-Hp-CoV Nsp1 and eIF1 bound to the human 40S small ribosomal subunit

Summary for 8PPK

• Entry DOI: 10.2210/pdb8ppk/pdb
• Related: 8PPL
• EMDB information: 17804
• Descriptor: Eukaryotic translation initiation factor 1, 40S ribosomal protein S7, 40S ribosomal protein S8, ... (40 entities in total)
• Functional Keywords: nsp1, mers, sars, sars-cov2, ribosome, 40s ribosomal subunit, translation inhibition, coronavirus, 43s pic, 43s pre-initiation complex, mrna channel, initiation factor, eif2, eif3, eif1, eif1a, viral protein, translation
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 37
• Total formula weight: 1271012.02

Authors

Schubert, K.,Karousis, E.D.,Ban, I.,Lapointe, C.P.,Leibundgut, M.,Baeumlin, E.,Kummerant, E.,Scaiola, A.,Schoenhut, T.,Ziegelmueller, J.,Puglisi, J.D.,Muehlemann, O.,Ban, N. (deposition date: 2023-07-07, release date: 2023-10-18, Last modification date: 2024-04-24)

• Primary citation: Schubert, K.,Karousis, E.D.,Ban, I.,Lapointe, C.P.,Leibundgut, M.,Baumlin, E.,Kummerant, E.,Scaiola, A.,Schonhut, T.,Ziegelmuller, J.,Puglisi, J.D.,Muhlemann, O.,Ban, N.; Universal features of Nsp1-mediated translational shutdown by coronaviruses.; Mol.Cell, 83:3546-3557.e8, 2023; PubMed: 37802027; DOI: 10.1016/j.molcel.2023.09.002

Experimental method

ELECTRON MICROSCOPY (2.98 Å)