Summary for 4UG0
| Entry DOI | 10.2210/pdb4ug0/pdb |
| EMDB information | 2938 |
| Descriptor | 28S ribosomal RNA, 60S RIBOSOMAL PROTEIN L7A, 60S RIBOSOMAL PROTEIN L9, ... (83 entities in total) |
| Functional Keywords | ribosome |
| Biological source | HOMO SAPIENS (HUMAN) More |
| Total number of polymer chains | 81 |
| Total formula weight | 3835516.96 |
| Authors | Khatter, H.,Myasnikov, A.G.,Natchiar, S.K.,Klaholz, B.P. (deposition date: 2015-03-20, release date: 2015-06-10, Last modification date: 2024-11-06) |
| Primary citation | Khatter, K.,Mysanikov, A.G.,Natchiar, S.K.,Klaholz, B.P. Structure of the human 80S ribosome NATURE, 520:640-645, 2015 Cited by PubMed Abstract: Ribosomes are translational machineries that catalyse protein synthesis. Ribosome structures from various species are known at the atomic level, but obtaining the structure of the human ribosome has remained a challenge; efforts to address this would be highly relevant with regard to human diseases. Here we report the near-atomic structure of the human ribosome derived from high-resolution single-particle cryo-electron microscopy and atomic model building. The structure has an average resolution of 3.6 Å, reaching 2.9 Å resolution in the most stable regions. It provides unprecedented insights into ribosomal RNA entities and amino acid side chains, notably of the transfer RNA binding sites and specific molecular interactions with the exit site tRNA. It reveals atomic details of the subunit interface, which is seen to remodel strongly upon rotational movements of the ribosomal subunits. Furthermore, the structure paves the way for analysing antibiotic side effects and diseases associated with deregulated protein synthesis. PubMed: 25901680DOI: 10.1038/nature14427 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
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