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8ID8
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Cryo-EM structure of the TUG891 bound GPR120-Gi complex
Descriptor: 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J.
Deposit date:2023-02-12
Release date:2023-03-15
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
8IRS
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BU of 8irs by Molmil
Dopamine Receptor D2R-Gi-Rotigotine complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E.
Deposit date:2023-03-19
Release date:2023-06-07
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural genomics of the human dopamine receptor system.
Cell Res., 33, 2023
7YS6
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BU of 7ys6 by Molmil
Cryo-EM structure of the Serotonin 6 (5-HT6) receptor-DNGs-scFv16 complex
Descriptor: 5-hydroxytryptamine receptor 6, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhao, Q.Y, Wang, Y.F, He, L, Wang, S, Cong, Y.
Deposit date:2022-08-11
Release date:2023-03-29
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into constitutive activity of 5-HT 6 receptor.
Proc.Natl.Acad.Sci.USA, 120, 2023
7JNI
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BU of 7jni by Molmil
Crystal structure of the angiotensin II type 2 receptoror (AT2R) in complex with EMA401
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, FORMIC ACID, HEXANE-1,6-DIOL, ...
Authors:Cherezov, V, Shaye, H, Han, G.W.
Deposit date:2020-08-04
Release date:2022-02-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of the angiotensin II type 2 receptor AT 2 R is a novel therapeutic strategy for glioblastoma.
Proc.Natl.Acad.Sci.USA, 119, 2022
7EJ8
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BU of 7ej8 by Molmil
Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to brimonidine
Descriptor: Alpha-2A adrenergic receptor, Brimonidine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Xu, J, Cao, S, Liu, Z, Du, Y.
Deposit date:2021-04-01
Release date:2022-04-13
Last modified:2022-10-26
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor.
Sci Adv, 8, 2022
8TH3
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BU of 8th3 by Molmil
Structure of AT118-H Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor
Descriptor: AT118-H nanobody, Type-1 angiotensin II receptor, Soluble cytochrome b562 complex, ...
Authors:Skiba, M.A, Kruse, A.C.
Deposit date:2023-07-13
Release date:2024-05-22
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Antibodies expand the scope of angiotensin receptor pharmacology.
Nat.Chem.Biol., 2024
7CFN
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BU of 7cfn by Molmil
Cryo-EM structure of the INT-777-bound GPBAR-Gs complex
Descriptor: (2S,4R)-4-[(3R,5S,6R,7R,8R,9S,10S,12S,13R,14S,17R)-6-ethyl-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-pentanoic acid, CHOLESTEROL, G-protein coupled bile acid receptor 1, ...
Authors:Yang, F, Mao, C, Guo, L, Lin, J, Ming, Q, Xiao, P, Wu, X, Shen, Q, Guo, S, Shen, D, Lu, R, Zhang, L, Huang, S, Ping, Y, Zhang, C, Ma, C, Zhang, K, Liang, X, Shen, Y, Nan, F, Yi, F, Luca, V, Zhou, J, Jiang, C, Sun, J, Xie, X, Yu, X, Zhang, Y.
Deposit date:2020-06-27
Release date:2020-09-09
Last modified:2021-04-07
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis of GPBAR activation and bile acid recognition.
Nature, 587, 2020
6BQG
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BU of 6bqg by Molmil
Crystal structure of 5-HT2C in complex with ergotamine
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, Ergotamine
Authors:Peng, Y, McCorvy, J.D, Harpsoe, K, Lansu, K, Yuan, S, Popov, P, Qu, L, Pu, M, Che, T, Nikolajse, L.F, Huang, X.P, Wu, Y, Shen, L, Bjorn-Yoshimoto, W.E, Ding, K, Wacker, D, Han, G.W, Cheng, J, Katritch, V, Jensen, A.A, Hanson, M.A, Zhao, S, Gloriam, D.E, Roth, B.L, Stevens, R.C, Liu, Z.
Deposit date:2017-11-27
Release date:2018-02-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Cell, 172, 2018
7F1R
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BU of 7f1r by Molmil
Cryo-EM structure of the chemokine receptor CCR5 in complex with RANTES and Gi
Descriptor: C-C motif chemokine 5,C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B.
Deposit date:2021-06-09
Release date:2021-07-14
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5.
Nat Commun, 12, 2021
7L1V
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BU of 7l1v by Molmil
Orexin Receptor 2 (OX2R) in Complex with G Protein and Small-Molecule Agonist Compound 1
Descriptor: 4'-methoxy-N,N-dimethyl-3'-{[3-(2-{[2-(2H-1,2,3-triazol-2-yl)benzene-1-carbonyl]amino}ethyl)phenyl]sulfamoyl}[1,1'-biphenyl]-3-carboxamide, Engineered Guanine nucleotide-binding protein subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Hong, C, Byrne, N.J, Zamlynny, B, Tummala, S, Xiao, L, Shipman, J.M, Partridge, A.T, Minnick, C, Breslin, M.J, Rudd, M.T, Stachel, S.J, Rada, V.L, Kern, J.C, Armacost, K.A, Hollingsworth, S.A, O'Brien, J.A, Hall, D.L, McDonald, T.P, Strickland, C, Brooun, A, Soisson, S.M, Hollenstein, K.
Deposit date:2020-12-15
Release date:2021-02-10
Last modified:2021-02-17
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation.
Nat Commun, 12, 2021
6N4B
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BU of 6n4b by Molmil
Cannabinoid Receptor 1-G Protein Complex
Descriptor: CHOLESTEROL, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Krishna Kumar, K, Shalev-Benami, M, Hu, H, Weis, W.I, Kobilka, B.K, Skiniotis, G.
Deposit date:2018-11-18
Release date:2019-01-30
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.
Cell, 176, 2019
5TUD
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BU of 5tud by Molmil
Structural Insights into the Extracellular Recognition of the Human Serotonin 2B Receptor by an Antibody
Descriptor: 5-hydroxytryptamine receptor 2B,Soluble cytochrome b562 chimera, Anti-5-HT2B Fab heavy chain, Anti-5-HT2B Fab light chain, ...
Authors:Ishchenko, A, Wacker, D, Kapoor, M, Zhang, A, Han, G.W, Basu, S, Boutet, S, James, D, Wang, D, Weierstall, U, Liu, W, Katritch, V, Stevens, R.C, Cherezov, V.
Deposit date:2016-11-05
Release date:2017-07-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
7F4D
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BU of 7f4d by Molmil
Cryo-EM structure of alpha-MSH-bound melanocortin-1 receptor in complex with Gs protein and Nb35
Descriptor: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E.
Deposit date:2021-06-18
Release date:2021-09-08
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor.
Cell Res., 31, 2021
6A93
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BU of 6a93 by Molmil
Crystal structure of 5-HT2AR in complex with risperidone
Descriptor: 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, CHOLESTEROL, ...
Authors:Kimura, T.K, Asada, H, Inoue, A, Kadji, F.M.N, Im, D, Mori, C, Arakawa, T, Hirata, K, Nomura, Y, Nomura, N, Aoki, J, Iwata, S, Shimamura, T.
Deposit date:2018-07-11
Release date:2019-02-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of the 5-HT2Areceptor in complex with the antipsychotics risperidone and zotepine.
Nat.Struct.Mol.Biol., 26, 2019
7F54
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BU of 7f54 by Molmil
Cryo-EM structure of afamelanotide-MC4R-Gs_Nb35 complex
Descriptor: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J.
Deposit date:2021-06-21
Release date:2021-11-03
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Cell Res., 31, 2021
7F53
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BU of 7f53 by Molmil
Cryo-EM structure of a-MSH-MC4R-Gs_Nb35 complex
Descriptor: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J.
Deposit date:2021-06-21
Release date:2021-11-03
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Cell Res., 31, 2021
7F8X
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BU of 7f8x by Molmil
Crystal structure of the cholecystokinin receptor CCKAR in complex with NN9056
Descriptor: ASP-SMF-NLE-GLY-TRP-NLE-OEM-MEA-NH2 (NN9056), Cholecystokinin receptor type A,Endolysin
Authors:Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2021-07-02
Release date:2021-12-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Nat.Chem.Biol., 17, 2021
5DHH
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BU of 5dhh by Molmil
The crystal structure of nociceptin/orphanin FQ peptide receptor (NOP) in complex with SB-612111 (PSI Community Target)
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (5S,7S)-7-{[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl}-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol, OLEIC ACID, ...
Authors:Miller, R.L, Thompson, A.A, Trapella, C, Guerrini, R, Malfacini, D, Patel, N, Han, G.W, Cherezov, V, Calo, G, Katritch, V, Stevens, R.C, GPCR Network (GPCR)
Deposit date:2015-08-31
Release date:2015-10-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.004 Å)
Cite:The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor.
Structure, 23, 2015
8WSS
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BU of 8wss by Molmil
Cryo-EM structure of Melanin-Concentrating Hormone Receptor 1 with MCH
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Zhao, L, He, Q, Yuan, Q, Gu, Y, Shan, H, Hu, W, Wu, K, Xu, H.E, Zhang, Y, Wu, C.
Deposit date:2023-10-17
Release date:2024-06-19
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors.
Cell Discov, 10, 2024
8HCQ
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BU of 8hcq by Molmil
Cryo-EM structure of endothelin1-bound ETAR-Gq complex
Descriptor: Endothelin-1, Endothelin-1 receptor,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Yuan, Q, Jiang, Y, Xu, H.E, Ji, Y, Duan, J.
Deposit date:2022-11-02
Release date:2023-03-22
Last modified:2023-10-04
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Structural basis of peptide recognition and activation of endothelin receptors.
Nat Commun, 14, 2023
8JXW
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BU of 8jxw by Molmil
VUF6884-bound H4R/Gi complex
Descriptor: 2-chloranyl-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:He, Y, Xia, R.
Deposit date:2023-07-01
Release date:2024-03-20
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Structural basis of ligand recognition and design of antihistamines targeting histamine H 4 receptor.
Nat Commun, 15, 2024
8H2G
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BU of 8h2g by Molmil
Cryo-EM structure of niacin bound human hydroxy-carboxylic acid receptor 2 in complex with Gi heterotrimer
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Park, J.H, Ishimoto, N, Park, S.Y.
Deposit date:2022-10-06
Release date:2023-10-11
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Structural basis for hydroxy-carboxylic acid receptor 2 activation and allosteric mechanism
To Be Published
8HNK
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BU of 8hnk by Molmil
CXCR3-DNGi complex activated by CXCL11
Descriptor: C-X-C motif chemokine 11, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Jiao, H.Z, Hu, H.L.
Deposit date:2022-12-08
Release date:2023-11-29
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Structural insights into the activation and inhibition of CXC chemokine receptor 3.
Nat.Struct.Mol.Biol., 31, 2024
7WKD
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BU of 7wkd by Molmil
TRH-TRHR G protein complex
Descriptor: Gq, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Xu, Y, Cai, H, You, C, He, X, Yuan, Q, Jiang, H, Cheng, X, Jiang, Y, Xu, H.E.
Deposit date:2022-01-09
Release date:2022-06-15
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Structural insights into ligand binding and activation of the human thyrotropin-releasing hormone receptor.
Cell Res., 32, 2022
6TP4
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BU of 6tp4 by Molmil
Crystal structure of the Orexin-1 receptor in complex with ACT-462206
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, (2~{S})-~{N}-(3,5-dimethylphenyl)-1-(4-methoxyphenyl)sulfonyl-pyrrolidine-2-carboxamide, Orexin receptor type 1, ...
Authors:Rappas, M, Ali, A, Bennett, K.A, Brown, J.D, Bucknell, S.J, Congreve, M, Cooke, R.M, Cseke, G, de Graaf, C, Dore, A.S, Errey, J.C, Jazayeri, A, Marshall, F.H, Mason, J.S, Mould, R, Patel, J.C, Tehan, B.G, Weir, M, Christopher, J.A.
Deposit date:2019-12-12
Release date:2020-01-01
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.011 Å)
Cite:Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
J.Med.Chem., 63, 2020

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