8TH3

Structure of AT118-H Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor

Summary for 8TH3

Entry DOI	10.2210/pdb8th3/pdb
EMDB information	41248 41249
Descriptor	AT118-H nanobody, Type-1 angiotensin II receptor, Soluble cytochrome b562 complex, BAG2 Anti-BRIL Fab Heavy Chain, BAG2 Anti-BRIL Fab Light Chain, ... (4 entities in total)
Functional Keywords	g protein-coupled receptor, nanobody, signaling protein-immune system complex, signaling protein/immune system
Biological source	Camelidae More
Total number of polymer chains	4
Total formula weight	179783.30
Authors	Skiba, M.A.,Kruse, A.C. (deposition date: 2023-07-13, release date: 2024-05-22, Last modification date: 2024-05-29)
Primary citation	Skiba, M.A.,Sterling, S.M.,Rawson, S.,Zhang, S.,Xu, H.,Jiang, H.,Nemeth, G.R.,Gilman, M.S.A.,Hurley, J.D.,Shen, P.,Staus, D.P.,Kim, J.,McMahon, C.,Lehtinen, M.K.,Rockman, H.A.,Barth, P.,Wingler, L.M.,Kruse, A.C. Antibodies expand the scope of angiotensin receptor pharmacology. Nat.Chem.Biol., 2024 Cited by PubMed: 38744986 DOI: 10.1038/s41589-024-01620-6 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation