8TH3
Structure of AT118-H Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004945 | molecular_function | angiotensin type II receptor activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019229 | biological_process | regulation of vasoconstriction |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0004945 | molecular_function | angiotensin type II receptor activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016020 | cellular_component | membrane |
| B | 0019229 | biological_process | regulation of vasoconstriction |
| B | 0020037 | molecular_function | heme binding |
| B | 0022900 | biological_process | electron transport chain |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVfLLTCLSIDRYLaI |
| Chain | Residue | Details |
| A | ALA114-ILE130 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| D | TYR194-HIS200 | |
| C | TYR208-HIS214 |
| site_id | PS00324 |
| Number of Residues | 9 |
| Details | ASPARTOKINASE Aspartokinase signature. LlKYGGSSL |
| Chain | Residue | Details |
| A | LEU1316-LEU1324 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 29 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"25913193","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26420482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30639100","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32079768","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZUD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25913193","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26420482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30639100","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32079768","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZUD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"25913193","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26420482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30639100","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32079768","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZUD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"25913193","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26420482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30639100","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32079768","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZUD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"25913193","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26420482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30639100","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32079768","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZUD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"25913193","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26420482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30639100","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32079768","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZUD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"25913193","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26420482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30639100","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32079768","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZUD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"25913193","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26420482","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZUD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 9 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"25913193","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26420482","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZUD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"25913193","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26420482","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZUD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30639100","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32079768","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6DO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"30639100","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32079768","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OS0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
