6A93

Crystal structure of 5-HT2AR in complex with risperidone

Summary for 6A93

Descriptor5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, CHOLESTEROL, ... (6 entities in total)
Functional Keywordsmembrane protein
Biological sourceHomo sapiens (Human)
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Total number of polymer chains2
Total molecular weight86493.05
Authors
Primary citation
Kimura, T.K.,Asada, H.,Inoue, A.,Kadji, F.M.N.,Im, D.,Mori, C.,Arakawa, T.,Hirata, K.,Nomura, Y,Nomura, N.,Aoki, J.,Iwata, S.,Shimamura, T.
Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepin
Nat.Struct.Mol.Biol., 26:121-128, 2019
DOI: 10.1038/s41594-018-0180-z
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27550 1.4% 4.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution