8IRS

Dopamine Receptor D2R-Gi-Rotigotine complex

Summary for 8IRS

• Entry DOI: 10.2210/pdb8irs/pdb
• EMDB information: 35684
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ScFv16, ... (6 entities in total)
• Functional Keywords: dopamine, dopamine receptor, gpcr, d2r, gi, rotigotine, polypharmacology parkinson's disease, restless legs syndrome, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 180207.22

Authors

Xu, P.,Huang, S.,Zhuang, Y.,Mao, C.,Zhang, Y.,Wang, Y.,Li, H.,Jiang, Y.,Zhang, Y.,Xu, H.E. (deposition date: 2023-03-19, release date: 2023-06-07, Last modification date: 2023-11-08)

• Primary citation: Xu, P.,Huang, S.,Krumm, B.E.,Zhuang, Y.,Mao, C.,Zhang, Y.,Wang, Y.,Huang, X.P.,Liu, Y.F.,He, X.,Li, H.,Yin, W.,Jiang, Y.,Zhang, Y.,Roth, B.L.,Xu, H.E.; Structural genomics of the human dopamine receptor system.; Cell Res., 33:604-616, 2023; PubMed: 37221270; DOI: 10.1038/s41422-023-00808-0

Experimental method

ELECTRON MICROSCOPY (3 Å)