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8IRS

Dopamine Receptor D2R-Gi-Rotigotine complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005813cellular_componentcentrosome
A0005834cellular_componentheterotrimeric G-protein complex
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0019003molecular_functionGDP binding
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031749molecular_functionD2 dopamine receptor binding
A0031821molecular_functionG protein-coupled serotonin receptor binding
A0043434biological_processresponse to peptide hormone
A0043949biological_processregulation of cAMP-mediated signaling
A0046872molecular_functionmetal ion binding
A0051301biological_processcell division
A0060236biological_processregulation of mitotic spindle organization
A0070062cellular_componentextracellular exosome
A0072678biological_processT cell migration
A1904322biological_processcellular response to forskolin
A1904778biological_processpositive regulation of protein localization to cell cortex
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0000139cellular_componentGolgi membrane
R0001591molecular_functiondopamine neurotransmitter receptor activity, coupled via Gi/Go
R0001659biological_processtemperature homeostasis
R0001666biological_processresponse to hypoxia
R0001669cellular_componentacrosomal vesicle
R0001764biological_processneuron migration
R0001933biological_processnegative regulation of protein phosphorylation
R0001964biological_processstartle response
R0001965molecular_functionG-protein alpha-subunit binding
R0001975biological_processresponse to amphetamine
R0001976biological_processnervous system process involved in regulation of systemic arterial blood pressure
R0002027biological_processregulation of heart rate
R0002028biological_processregulation of sodium ion transport
R0002031biological_processG protein-coupled receptor internalization
R0002052biological_processpositive regulation of neuroblast proliferation
R0002092biological_processpositive regulation of receptor internalization
R0004930molecular_functionG protein-coupled receptor activity
R0004952molecular_functiondopamine neurotransmitter receptor activity
R0005102molecular_functionsignaling receptor binding
R0005506molecular_functioniron ion binding
R0005515molecular_functionprotein binding
R0005794cellular_componentGolgi apparatus
R0005886cellular_componentplasma membrane
R0005929cellular_componentcilium
R0006914biological_processautophagy
R0007186biological_processG protein-coupled receptor signaling pathway
R0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
R0007195biological_processadenylate cyclase-inhibiting dopamine receptor signaling pathway
R0007212biological_processG protein-coupled dopamine receptor signaling pathway
R0007270biological_processneuron-neuron synaptic transmission
R0007405biological_processneuroblast proliferation
R0007409biological_processaxonogenesis
R0007416biological_processsynapse assembly
R0007608biological_processsensory perception of smell
R0007616biological_processlong-term memory
R0007625biological_processgrooming behavior
R0007626biological_processlocomotory behavior
R0007628biological_processadult walking behavior
R0007631biological_processfeeding behavior
R0008104biological_processprotein localization
R0008283biological_processcell population proliferation
R0008285biological_processnegative regulation of cell population proliferation
R0008306biological_processassociative learning
R0008542biological_processvisual learning
R0009055molecular_functionelectron transfer activity
R0009410biological_processresponse to xenobiotic stimulus
R0009416biological_processresponse to light stimulus
R0009636biological_processresponse to toxic substance
R0010039biological_processresponse to iron ion
R0014059biological_processregulation of dopamine secretion
R0014854biological_processresponse to inactivity
R0016020cellular_componentmembrane
R0016055biological_processWnt signaling pathway
R0016328cellular_componentlateral plasma membrane
R0016477biological_processcell migration
R0020037molecular_functionheme binding
R0021756biological_processstriatum development
R0021769biological_processorbitofrontal cortex development
R0021853biological_processcerebral cortex GABAergic interneuron migration
R0021984biological_processadenohypophysis development
R0022900biological_processelectron transport chain
R0030139cellular_componentendocytic vesicle
R0030336biological_processnegative regulation of cell migration
R0030424cellular_componentaxon
R0030425cellular_componentdendrite
R0030432biological_processperistalsis
R0030534biological_processadult behavior
R0030672cellular_componentsynaptic vesicle membrane
R0030900biological_processforebrain development
R0031223biological_processauditory behavior
R0032228biological_processregulation of synaptic transmission, GABAergic
R0032467biological_processpositive regulation of cytokinesis
R0032795molecular_functionheterotrimeric G-protein binding
R0032922biological_processcircadian regulation of gene expression
R0033602biological_processnegative regulation of dopamine secretion
R0034776biological_processresponse to histamine
R0035094biological_processresponse to nicotine
R0035240molecular_functiondopamine binding
R0035255molecular_functionionotropic glutamate receptor binding
R0035810biological_processpositive regulation of urine volume
R0035815biological_processpositive regulation of renal sodium excretion
R0036126cellular_componentsperm flagellum
R0040018biological_processpositive regulation of multicellular organism growth
R0042220biological_processresponse to cocaine
R0042321biological_processnegative regulation of circadian sleep/wake cycle, sleep
R0042417biological_processdopamine metabolic process
R0042597cellular_componentperiplasmic space
R0042734cellular_componentpresynaptic membrane
R0042756biological_processdrinking behavior
R0042802molecular_functionidentical protein binding
R0043197cellular_componentdendritic spine
R0043204cellular_componentperikaryon
R0043266biological_processregulation of potassium ion transport
R0043278biological_processresponse to morphine
R0043408biological_processregulation of MAPK cascade
R0043410biological_processpositive regulation of MAPK cascade
R0043473biological_processpigmentation
R0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
R0043679cellular_componentaxon terminus
R0044877molecular_functionprotein-containing complex binding
R0045211cellular_componentpostsynaptic membrane
R0045471biological_processresponse to ethanol
R0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
R0045776biological_processnegative regulation of blood pressure
R0045824biological_processnegative regulation of innate immune response
R0045944biological_processpositive regulation of transcription by RNA polymerase II
R0046676biological_processnegative regulation of insulin secretion
R0046717biological_processacid secretion
R0046872molecular_functionmetal ion binding
R0048148biological_processbehavioral response to cocaine
R0048149biological_processbehavioral response to ethanol
R0048169biological_processregulation of long-term neuronal synaptic plasticity
R0048678biological_processresponse to axon injury
R0048755biological_processbranching morphogenesis of a nerve
R0050482biological_processarachidonic acid secretion
R0050673biological_processepithelial cell proliferation
R0050680biological_processnegative regulation of epithelial cell proliferation
R0050709biological_processnegative regulation of protein secretion
R0050769biological_processpositive regulation of neurogenesis
R0050804biological_processmodulation of chemical synaptic transmission
R0050805biological_processnegative regulation of synaptic transmission
R0051209biological_processrelease of sequestered calcium ion into cytosol
R0051481biological_processnegative regulation of cytosolic calcium ion concentration
R0051580biological_processregulation of neurotransmitter uptake
R0051583biological_processdopamine uptake involved in synaptic transmission
R0051584biological_processregulation of dopamine uptake involved in synaptic transmission
R0051586biological_processpositive regulation of dopamine uptake involved in synaptic transmission
R0051823biological_processregulation of synapse structural plasticity
R0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
R0051967biological_processnegative regulation of synaptic transmission, glutamatergic
R0060079biological_processexcitatory postsynaptic potential
R0060124biological_processpositive regulation of growth hormone secretion
R0060134biological_processprepulse inhibition
R0060158biological_processphospholipase C-activating dopamine receptor signaling pathway
R0060160biological_processnegative regulation of dopamine receptor signaling pathway
R0060170cellular_componentciliary membrane
R0070374biological_processpositive regulation of ERK1 and ERK2 cascade
R0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
R0090325biological_processregulation of locomotion involved in locomotory behavior
R0097159molecular_functionorganic cyclic compound binding
R0097648cellular_componentG protein-coupled receptor complex
R0097730cellular_componentnon-motile cilium
R0098691cellular_componentdopaminergic synapse
R0098978cellular_componentglutamatergic synapse
R0098982cellular_componentGABA-ergic synapse
R0099170biological_processpostsynaptic modulation of chemical synaptic transmission
R0099171biological_processpresynaptic modulation of chemical synaptic transmission
R1900038biological_processnegative regulation of cellular response to hypoxia
R1900168biological_processpositive regulation of glial cell-derived neurotrophic factor production
R1900273biological_processpositive regulation of long-term synaptic potentiation
R1901363molecular_functionheterocyclic compound binding
R1903530biological_processregulation of secretion by cell
R1990384biological_processhyaloid vascular plexus regression
R2001223biological_processnegative regulation of neuron migration
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIlNLCAISIDRYTaV
ChainResidueDetails
RALA120-VAL136

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: axial binding residue
ChainResidueDetails
RTRP-110
RILE-15

site_idSWS_FT_FI2
Number of Residues78
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
RMET1-TYR37
RLEU94-ASP108
RGLY173-ALA188
RASN396-SER409

site_idSWS_FT_FI3
Number of Residues22
DetailsTRANSMEM: Helical; Name=1 => ECO:0000250
ChainResidueDetails
RALA38-SER60

site_idSWS_FT_FI4
Number of Residues199
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
RARG61-ASN70
RASP131-ARG151
RILE214-GLN373
RGLU432-CYS443

site_idSWS_FT_FI5
Number of Residues22
DetailsTRANSMEM: Helical; Name=2 => ECO:0000250
ChainResidueDetails
RTYR71-TYR93

site_idSWS_FT_FI6
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000250
ChainResidueDetails
RILE109-ILE130

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000250
ChainResidueDetails
RVAL152-PHE172

site_idSWS_FT_FI8
Number of Residues24
DetailsTRANSMEM: Helical; Name=5 => ECO:0000250
ChainResidueDetails
RPHE189-TYR213

site_idSWS_FT_FI9
Number of Residues21
DetailsTRANSMEM: Helical; Name=6 => ECO:0000250
ChainResidueDetails
RMET374-LEU395

site_idSWS_FT_FI10
Number of Residues21
DetailsTRANSMEM: Helical; Name=7 => ECO:0000250
ChainResidueDetails
RALA410-ILE431

site_idSWS_FT_FI11
Number of Residues2
DetailsSITE: Important for receptor activation => ECO:0000250
ChainResidueDetails
RSER194
RSER197

site_idSWS_FT_FI12
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:26535572
ChainResidueDetails
RCYS443

site_idSWS_FT_FI13
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN5
RASN17
RASN23

222926

PDB entries from 2024-07-24

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